Compulsive alcohol drinking in rodents is associated with altered representations of behavioral control and seeking in dorsal medial prefrontal cortex

dc.contributor.authorTimme, Nicholas M.
dc.contributor.authorMa, Baofeng
dc.contributor.authorLinsenbardt, David
dc.contributor.authorCornwell , Ethan
dc.contributor.authorGalbari, Taylor
dc.contributor.authorLapish, Christopher C.
dc.contributor.departmentPsychology, School of Science
dc.date.accessioned2024-05-14T20:36:49Z
dc.date.available2024-05-14T20:36:49Z
dc.date.issued2022-07-09
dc.description.abstractA key feature of compulsive alcohol drinking is continuing to drink despite negative consequences. To examine the changes in neural activity that underlie this behavior, compulsive alcohol drinking was assessed in a validated rodent model of heritable risk for excessive drinking (alcohol preferring (P) rats). Neural activity was measured in dorsal medial prefrontal cortex (dmPFC—a brain region involved in maladaptive decision-making) and assessed via change point analyses and novel principal component analyses. Neural population representations of specific decision-making variables were measured to determine how they were altered in animals that drink alcohol compulsively. Compulsive animals showed weakened representations of behavioral control signals, but strengthened representations of alcohol seeking-related signals. Finally, chemogenetic-based excitation of dmPFC prevented escalation of compulsive alcohol drinking. Collectively, these data indicate that compulsive alcohol drinking in rats is associated with alterations in dmPFC neural activity that underlie diminished behavioral control and enhanced seeking.
dc.eprint.versionFinal published version
dc.identifier.citationTimme, N. M., Ma, B., Linsenbardt, D., Cornwell, E., Galbari, T., & Lapish, C. C. (2022). Compulsive alcohol drinking in rodents is associated with altered representations of behavioral control and seeking in dorsal medial prefrontal cortex—Nature Communications. Nature Communications, 13(1), 3990. https://doi.org/10.1038/s41467-022-31731-4
dc.identifier.urihttps://hdl.handle.net/1805/40748
dc.language.isoen_US
dc.publisherSpringer
dc.relation.isversionof10.1038/s41467-022-31731-4
dc.relation.journalNature Communications
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePublisher
dc.subjectNeural encoding
dc.subjectAddiction
dc.subjectMotivation
dc.subjectReward
dc.titleCompulsive alcohol drinking in rodents is associated with altered representations of behavioral control and seeking in dorsal medial prefrontal cortex
dc.typeArticle
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