Neurocognitive markers of childhood abuse in individuals with PTSD: Findings from the INTRuST Clinical Consortium

If you need an accessible version of this item, please submit a remediation request.
Date
2020-02-01
Language
American English
Embargo Lift Date
Committee Members
Degree
Degree Year
Department
Grantor
Journal Title
Journal ISSN
Volume Title
Found At
Elsevier
Abstract

To date, few studies have evaluated the contribution of early life experiences to neurocognitive abnormalities observed in posttraumatic stress disorder (PTSD). Childhood maltreatment is common among individuals with PTSD and is thought to catalyze stress-related biobehavioral changes that might impact both brain structure and function in adulthood. The current study examined differences in brain morphology (brain volume, cortical thickness) and neuropsychological performance in individuals with PTSD characterized by low or high self-reported childhood maltreatment, compared with healthy comparison participants. Data were drawn from the INjury and TRaUmatic STress (INTRuST) Clinical Consortium imaging repository, which contains MRI and self-report data for individuals classified as PTSD positive (with and without a history of mild traumatic brain injury [mTBI]), individuals with mTBI only, and healthy comparison participants. The final sample included 36 individuals with PTSD without childhood maltreatment exposure (PTSD, n = 30 with mTBI), 31 individuals with PTSD and childhood maltreatment exposure (PTSD + M, n = 26 with mTBI), and 114 healthy comparison participants without history of childhood maltreatment exposure (HC). The PTSD + M and PTSD groups demonstrated cortical thinning in prefrontal and occipital regions, and poorer verbal memory and processing speed compared to the HC group. PTSD + M participants demonstrated cortical thinning in frontal and cingulate regions, and poorer executive functioning relative to the PTSD and HC groups. Thus, neurocognitive features varied between individuals with PTSD who did versus did not have exposure to childhood maltreatment, highlighting the need to assess developmental history of maltreatment when examining biomarkers in PTSD.

Description
item.page.description.tableofcontents
item.page.relation.haspart
Cite As
Bomyea, J., Simmons, A. N., Shenton, M. E., Coleman, M. J., Bouix, S., Rathi, Y., Pasternak, O., Coimbra, R., Shutter, L., George, M. S., Grant, G., Zafonte, R. D., McAllister, T. W., & Stein, M. B. (2020). Neurocognitive markers of childhood abuse in individuals with PTSD: Findings from the INTRuST Clinical Consortium. Journal of Psychiatric Research, 121, 108–117. https://doi.org/10.1016/j.jpsychires.2019.11.012
ISSN
0022-3956
Publisher
Series/Report
Sponsorship
Major
Extent
Identifier
Relation
Journal
Journal of Psychiatric Research
Source
PMC
Alternative Title
Type
Article
Number
Volume
Conference Dates
Conference Host
Conference Location
Conference Name
Conference Panel
Conference Secretariat Location
Version
Author's manuscript
Full Text Available at
This item is under embargo {{howLong}}