Glucocorticoid Induced Leucine Zipper in Lipopolysaccharide Induced Neuroinflammation

dc.contributor.authorWitek, Emily
dc.contributor.authorHickman, Debra
dc.contributor.authorLahiri, Debomoy K.
dc.contributor.authorSrinivasan, Mythily
dc.contributor.departmentPsychiatry, School of Medicineen_US
dc.date.accessioned2019-07-31T18:37:28Z
dc.date.available2019-07-31T18:37:28Z
dc.date.issued2019-01-25
dc.description.abstractGlucocorticoids (GCs) are steroid hormones secreted as the end-product of the neuroendocrine stress cascade. Both absence and elevated GC mediate neurotoxic responses, suggesting that a narrow window ranging from physiological to slightly high GC mediate protective responses. The beneficial effects of GC are attributed to the transactivation of regulatory proteins and inhibition mediated by glucocorticoid receptor (GR) interactions with other co-factors. The glucocorticoid induced leucine zipper (GILZ) is a gene strongly upregulated by GC and mediates many of the anti-inflammatory and anti-proliferative effects of GC. Although GILZ is constitutively expressed in many tissues including the brain, the expression has been shown to occur with varying dynamics suggesting that the local milieu modulates its expression with consequent effects on cellular responses. Here we investigated the expression profile of GILZ in lipopolysaccharide (LPS) mediated neuroinflammation model of Alzheimer’s disease (AD). Our data suggest that the GILZ expression is downregulated in neuroinflammation correlating inversely with the pro-inflammatory cytokines and innate immune responses.en_US
dc.identifier.citationWitek, E., Hickman, D., Lahiri, D. K., & Srinivasan, M. (2019). Glucocorticoid Induced Leucine Zipper in Lipopolysaccharide Induced Neuroinflammation. Frontiers in aging neuroscience, 10, 432. doi:10.3389/fnagi.2018.00432en_US
dc.identifier.urihttps://hdl.handle.net/1805/20076
dc.language.isoen_USen_US
dc.publisherFrontiersen_US
dc.relation.isversionof10.3389/fnagi.2018.00432en_US
dc.relation.journalFrontiers in Aging Neuroscienceen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.sourcePMCen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectCytokinesen_US
dc.subjectGlucocorticoid induced leucine zipperen_US
dc.subjectNeuroinflammationen_US
dc.subjectToll like receptor-4en_US
dc.titleGlucocorticoid Induced Leucine Zipper in Lipopolysaccharide Induced Neuroinflammationen_US
dc.typeArticleen_US
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