Locally advanced adenocarcinoma and adenosquamous carcinomas of the cervix compared to squamous cell carcinomas of the cervix in gynecologic oncology group trials of cisplatin-based chemoradiation
dc.contributor.author | Rose, Peter G. | |
dc.contributor.author | Java, James J. | |
dc.contributor.author | Whitney, Charles W. | |
dc.contributor.author | Stehman, Frederick B. | |
dc.contributor.author | Lanciano, Rachelle | |
dc.contributor.author | Thomas, Gillian M. | |
dc.contributor.department | Department of Obstetrics and Gynecology, IU School of Medicine | en_US |
dc.date.accessioned | 2016-10-12T18:13:07Z | |
dc.date.available | 2016-10-12T18:13:07Z | |
dc.date.issued | 2014-11 | |
dc.description.abstract | OBJECTIVE: Conflicting results have been reported for adeno- and adenosquamous carcinomas of the cervix with respect to their response to therapy and prognosis. The current study sought to evaluate impact of adeno- and adenosquamous histology in the randomized trials of primary cisplatin-based chemoradiation for locally advanced cervical cancer. METHODS: Patients with adeno- and adenosquamous cervical carcinomas were retrospectively studied and compared to squamous cell carcinomas in GOG trials of chemoradiation. RESULTS: Among 1671 enrolled in clinical trials of chemoradiation, 182 adeno- and adenosquamous carcinomas were identified (10.9%). A higher percentage of adeno- and adenosquamous carcinomas were stage IB2 (27.5% versus 20.0%) and fewer had stage IIIB (21.4% versus 28.6%). The mean tumor size was larger for squamous than adeno- and adenosquamous. Adeno- and adenosquamous carcinomas were more often poorly differentiated (46.2% versus 26.8%). When treated with radiation therapy alone, the 70 patients with adeno- and adenosquamous carcinoma of the cervix showed a statistically poorer overall survival (p=0.0499) compared to the 647 patients with squamous cell carcinoma of the cervix. However, when treated with radiation therapy with concurrent cisplatin-based chemotherapy, the 112 patients with adeno- and adenosquamous carcinomas had a similar overall survival (p=0.459) compared the 842 patients with squamous cell carcinoma. Adverse effects to treatment were similar across histologies. CONCLUSION: Adeno- and adenosquamous carcinomas of the cervix are associated with worse overall survival when treated with radiation alone but with similar progression-free and overall survival compared to squamous cell carcinomas of the cervix when treated with cisplatin based chemoradiation. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Rose, P. G., Java, J. J., Whitney, C. W., Stehman, F. B., Lanciano, R., & Thomas, G. M. (2014). Locally advanced adenocarcinoma and adenosquamous carcinomas of the cervix compared to squamous cell carcinomas of the cervix in Gynecologic Oncology Group trials of cisplatin-based chemoradiation. Gynecologic Oncology, 135(2), 208–212. http://doi.org/10.1016/j.ygyno.2014.08.018 | en_US |
dc.identifier.issn | 1095-6859 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/11164 | |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.ygyno.2014.08.018 | en_US |
dc.relation.journal | Gynecologic Oncology | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Adenocarcinoma | en_US |
dc.subject | therapy | en_US |
dc.subject | Antineoplastic Combined Chemotherapy Protocols | en_US |
dc.subject | therapeutic use | en_US |
dc.subject | Carcinoma, Adenosquamous | en_US |
dc.subject | Carcinoma, Squamous Cell | en_US |
dc.subject | Chemoradiotherapy | en_US |
dc.subject | methods | en_US |
dc.subject | Uterine Cervical Neoplasms | en_US |
dc.title | Locally advanced adenocarcinoma and adenosquamous carcinomas of the cervix compared to squamous cell carcinomas of the cervix in gynecologic oncology group trials of cisplatin-based chemoradiation | en_US |
dc.type | Article | en_US |