Cell-Cell Communication Breakdown and Endothelial Dysfunction

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2020-04
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American English
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Elsevier
Abstract

Guided by organ-specific signals in both development and disease response, the heterogeneous endothelial cell population is a dynamic member of the vasculature. Functioning as the gatekeeper to fluid, inflammatory cells, oxygen, and nutrients, endothelial cell communication with its local environment is critical. Impairment of endothelial cell-cell communication not only disrupts this signaling process, but also contributes to pathologic disease progression. Expanding our understanding of those processes that mediate endothelial cell-cell communication is an important step in the approach to treatment of disease processes.

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Lee DD, Schwarz MA. Cell-Cell Communication Breakdown and Endothelial Dysfunction. Crit Care Clin. 2020;36(2):189-200. doi:10.1016/j.ccc.2019.11.001
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Critical Care Clinics
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