Phase Coexistence in Single-Lipid Membranes Induced by Buffering Agents

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dc.contributor.authorJohnson, Merrell A.
dc.contributor.authorSeifert, Soenke
dc.contributor.authorPetrache, Horia I.
dc.contributor.authorKimble-Hill, Ann C.
dc.contributor.departmentDepartment of Biochemistry & Molecular Biology, IU School of Medicineen_US
dc.date.accessioned2016-02-25T17:17:05Z
dc.date.available2016-02-25T17:17:05Z
dc.date.issued2014-08-26
dc.description.abstractRecent literature has shown that buffers affect the interaction between lipid bilayers through a mechanism that involves van der Waals forces, electrostatics, hydration forces and membrane bending rigidity. This letter shows an additional peculiar effect of buffers on the mixed chain 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) lipid bilayers, namely phase coexistence similar to what was reported by Rappolt et al. for alkali chlorides. The data presented suggest that one phase appears to dehydrate below the value in pure water, while the other phase swells as the concentration of buffer is increased. However, since the two phases must be in osmotic equilibrium with one another, this behavior challenges theoretical models of lipid interactions.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationJohnson, M. A., Seifert, S., Petrache, H. I., & Kimble-Hill, A. C. (2014). Phase Coexistence in Single-Lipid Membranes Induced by Buffering Agents. Langmuir, 30(33), 9880–9885. http://doi.org/10.1021/la5018938en_US
dc.identifier.issn0743-7463en_US
dc.identifier.urihttps://hdl.handle.net/1805/8492
dc.language.isoen_USen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionof10.1021/la5018938en_US
dc.relation.journalLangmuiren_US
dc.rightsIUPUI Open Access Policyen_US
dc.sourcePublisheren_US
dc.subjectLipid Bilayersen_US
dc.subjectchemistryen_US
dc.subjectPhosphatidylcholinesen_US
dc.titlePhase Coexistence in Single-Lipid Membranes Induced by Buffering Agentsen_US
dc.typeArticleen_US
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