Effects of Gabapentin and Pregabalin on Calcium Homeostasis: Implications for Physical Rehabilitation of Musculoskeletal Tissues
dc.contributor.author | Reyes Fernandez, Perla C. | |
dc.contributor.author | Wright, Christian S. | |
dc.contributor.author | Warden, Stuart J. | |
dc.contributor.author | Hum, Julia | |
dc.contributor.author | Farach-Carson, Mary C. | |
dc.contributor.author | Thompson, William R. | |
dc.contributor.department | Physical Therapy, School of Health and Human Sciences | |
dc.date.accessioned | 2023-12-15T12:40:27Z | |
dc.date.available | 2023-12-15T12:40:27Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Purpose of review: In this review, we discuss the mechanism of action of gabapentinoids and the potential consequences of long-term treatment with these drugs on the musculoskeletal system. Recent findings: Gabapentinoids, such as gabapentin (GBP) and pregabalin (PGB) were designed as antiepileptic reagents and are now commonly used as first-line treatment for neuropathic pain and increasingly prescribed off-label for other pain disorders such as migraines and back pain. GBP and PGB exert their analgesic actions by selectively binding the α2δ1 auxiliary subunit of voltage-sensitive calcium channels, thereby inhibiting channel function. Numerous tissues express the α2δ1 subunit where GBP and PGB can alter calcium-mediated signaling events. In tissues such as bone, muscle, and cartilage, α2δ1 has important roles in skeletal formation, mechanosensation, and normal tissue function/repair that may be affected by chronic use of gabapentinoids. Long-term use of gabapentinoids is associated with detrimental musculoskeletal outcomes, including increased fracture risk. Therefore, understanding potential complications is essential for clinicians to guide appropriate treatments. | |
dc.eprint.version | Author's manuscript | |
dc.identifier.citation | Reyes Fernandez PC, Wright CS, Warden SJ, Hum J, Farach-Carson MC, Thompson WR. Effects of Gabapentin and Pregabalin on Calcium Homeostasis: Implications for Physical Rehabilitation of Musculoskeletal Tissues. Curr Osteoporos Rep. 2022;20(6):365-378. doi:10.1007/s11914-022-00750-x | |
dc.identifier.uri | https://hdl.handle.net/1805/37360 | |
dc.language.iso | en_US | |
dc.publisher | Springer | |
dc.relation.isversionof | 10.1007/s11914-022-00750-x | |
dc.relation.journal | Current Osteoporosis Reports | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | Gabapentin | |
dc.subject | Pregabalin | |
dc.subject | α2δ1 | |
dc.subject | Bone | |
dc.subject | Muscle | |
dc.subject | Cartilage | |
dc.title | Effects of Gabapentin and Pregabalin on Calcium Homeostasis: Implications for Physical Rehabilitation of Musculoskeletal Tissues | |
dc.type | Article |