Infection and venous thromboembolism in patients undergoing colorectal surgery: what is the relationship?
dc.contributor.author | Monn, M. Francesca | |
dc.contributor.author | Hui, Xuan | |
dc.contributor.author | Lau, Brandyn D. | |
dc.contributor.author | Streiff, Michael | |
dc.contributor.author | Haut, Elliott R. | |
dc.contributor.author | Wick, Elizabeth C. | |
dc.contributor.author | Efron, Jonathan E. | |
dc.contributor.author | Gearhart, Susan L. | |
dc.contributor.department | Department of Urology, IU School of Medicine | en_US |
dc.date.accessioned | 2016-03-23T17:26:07Z | |
dc.date.available | 2016-03-23T17:26:07Z | |
dc.date.issued | 2014-04 | |
dc.description.abstract | BACKGROUND: There is evidence demonstrating an association between infection and venous thromboembolism. We recently identified this association in the postoperative setting; however, the temporal relationship between infection and venous thromboembolism is not well defined OBJECTIVE: We sought to determine the temporal relationship between venous thromboembolism and postoperative infectious complications in patients undergoing colorectal surgery. DESIGN, SETTING, AND PATIENTS: A retrospective cohort analysis was performed using data for patients undergoing colorectal surgery in the National Surgical Quality Improvement Project 2010 database. MAIN OUTCOME MEASURES: The primary outcome measures were the rate and timing of venous thromboembolism and postoperative infection among patients undergoing colorectal surgery during 30 postoperative days. RESULTS: Of 39,831 patients who underwent colorectal surgery, the overall rate of venous thromboembolism was 2.4% (n = 948); 729 (1.8%) patients were diagnosed with deep vein thrombosis, and 307 (0.77%) patients were diagnosed with pulmonary embolism. Eighty-eight (0.22%) patients were reported as developing both deep vein thrombosis and pulmonary embolism. Following colorectal surgery, the development of a urinary tract infection, pneumonia, organ space surgical site infection, or deep surgical site infection was associated with a significantly increased risk for venous thromboembolism. The majority (52%-85%) of venous thromboembolisms in this population occurred the same day or a median of 3.5 to 8 days following the diagnosis of infection. The approximate relative risk for developing any venous thromboembolism increased each day following the development of each type of infection (range, 0.40%-1.0%) in comparison with patients not developing an infection. LIMITATIONS: We are unable to account for differences in data collection, prophylaxis, and venous thromboembolism surveillance between hospitals in the database. Additionally, there is limited patient follow-up. CONCLUSIONS: These findings of a temporal association between infection and venous thromboembolism suggest a potential early indicator for using certain postoperative infectious complications as clinical warning signs that a patient is more likely to develop venous thromboembolism. Further studies into best practices for prevention are warranted. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Monn, M. F., Hui, X., Lau, B. D., Streiff, M., Haut, E. R., Wick, E. C., … Gearhart, S. L. (2014). Infection and Venous Thromboembolism in Patients Undergoing Colorectal Surgery: What Is the Relationship? Diseases of the Colon and Rectum, 57(4), 497–505. http://doi.org/10.1097/DCR.0000000000000054 | en_US |
dc.identifier.issn | 1530-0358 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/8999 | |
dc.language.iso | en_US | en_US |
dc.publisher | Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins | en_US |
dc.relation.isversionof | 10.1097/DCR.0000000000000054 | en_US |
dc.relation.journal | Diseases of the Colon and Rectum | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Pneumonia | en_US |
dc.subject | etiology | en_US |
dc.subject | Postoperative Complications | en_US |
dc.subject | Pulmonary Embolism | en_US |
dc.subject | Urinary Tract Infections | en_US |
dc.subject | Venous Thromboembolism | en_US |
dc.subject | Venous Thrombosis | en_US |
dc.title | Infection and venous thromboembolism in patients undergoing colorectal surgery: what is the relationship? | en_US |
dc.type | Article | en_US |
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