Ocular Hemodynamics and Glaucoma: The Role of Mathematical Modeling

dc.contributor.authorHarris, Alon
dc.contributor.authorGuidoboni, Giovanna
dc.contributor.authorArciero, Julia C.
dc.contributor.authorAmireskandari, Annahita
dc.contributor.authorTobe, Leslie A.
dc.contributor.authorSiesky, Brent A.
dc.contributor.departmentOphthalmology, School of Medicine
dc.date.accessioned2025-05-22T15:20:54Z
dc.date.available2025-05-22T15:20:54Z
dc.date.issued2013
dc.description.abstractPurpose: To discuss the role of mathematical modeling in studying ocular hemodynamics, with a focus on glaucoma. Methods: We reviewed recent literature on glaucoma, ocular blood flow, autoregulation, the optic nerve head, and the use of mathematical modeling in ocular circulation. Results: Many studies suggest that alterations in ocular hemodynamics play a significant role in the development, progression, and incidence of glaucoma. Although there is currently a limited number of studies involving mathematical modeling of ocular blood flow, regulation, and diseases (such as glaucoma), preliminary modeling work shows the potential of mathematical models to elucidate the mechanisms that contribute most significantly to glaucoma progression. Conclusion: Mathematical modeling is a useful tool when used synergistically with clinical and laboratory data in the study of ocular blood flow and glaucoma. The development of models to investigate the relationship between ocular hemodynamic alterations and glaucoma progression will provide a unique and useful method for studying the pathophysiology of glaucoma.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationHarris A, Guidoboni G, Arciero JC, Amireskandari A, Tobe LA, Siesky BA. Ocular hemodynamics and glaucoma: the role of mathematical modeling. Eur J Ophthalmol. 2013;23(2):139-146. doi:10.5301/ejo.5000255
dc.identifier.urihttps://hdl.handle.net/1805/48328
dc.language.isoen_US
dc.publisherSage
dc.relation.isversionof10.5301/ejo.5000255
dc.relation.journalEuropean Journal of Ophthalmology
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectBlood flow velocity
dc.subjectEye
dc.subjectHomeostasis
dc.subjectOptic disk
dc.subjectOptic nerve diseases
dc.titleOcular Hemodynamics and Glaucoma: The Role of Mathematical Modeling
dc.typeArticle
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