GCH1 haplotypes and cardiovascular risk in HIV

Date
2019-05
Language
English
Embargo Lift Date
Committee Members
Degree
Degree Year
Department
Grantor
Journal Title
Journal ISSN
Volume Title
Found At
Wolters Kluwer
Abstract

Heightened systemic inflammation contributes to cardiovascular (CVD) events in people living with HIV (PLWH), though not all PLWH develop CVD, thus suggesting a genetic modifying role. We examined GCH1 polymorphisms, which have been associated with reduced endothelial function in European populations with CVD and increased inflammation, in a racially diverse cohort of U.S. PLWH initiating antiretroviral therapy (ART). GCH1 polymorphisms differed by race and were not associated flow-mediated dilation or carotid intima media thickness before or after 48 weeks of ART.

Description
item.page.description.tableofcontents
item.page.relation.haspart
Cite As
Slaven, J., Haas, D., Liu, Z., Stein, J., Brown, T., & Gupta, S. (2019). GCH1 haplotypes and cardiovascular risk in HIV. Aids. https://doi.org/10.1097/QAD.0000000000002263
ISSN
Publisher
Series/Report
Sponsorship
Major
Extent
Identifier
Relation
Journal
AIDS
Rights
Publisher Policy
Source
Author
Alternative Title
Type
Article
Number
Volume
Conference Dates
Conference Host
Conference Location
Conference Name
Conference Panel
Conference Secretariat Location
Version
Author's manuscript
Full Text Available at
This item is under embargo {{howLong}}