Sympathetic Nerve Fibers in Human Cervical and Thoracic Vagus Nerves

dc.contributor.authorSeki, Atsuko
dc.contributor.authorGreen, Hunter R.
dc.contributor.authorLee, Thomas D.
dc.contributor.authorHong, LongSheng
dc.contributor.authorTan, Jian
dc.contributor.authorVinters, Harry V.
dc.contributor.authorChen, Peng-Sheng
dc.contributor.authorFishbein, Michael C.
dc.contributor.departmentDepartment of Medicine, IU School of Medicineen_US
dc.date.accessioned2016-01-28T15:43:22Z
dc.date.available2016-01-28T15:43:22Z
dc.date.issued2014-08
dc.description.abstractBackground Vagus nerve stimulation therapy (VNS) has been used for chronic heart failure (CHF), and is believed to improve imbalance of autonomic control by increasing parasympathetic activity. Although it is known that there is neural communication between the VN and the cervical sympathetic trunk, there are few data regarding the quantity and/or distribution of the sympathetic components within the VN. Objective To examine the sympathetic component within human VN and correlate these with the presence of cardiac and neurologic diseases. Methods We performed immunohistochemistry on 31 human cervical and thoracic VNs (total 104 VNs) from autopsies and we reviewed the patients’ records. We correlated the quantity of sympathetic nerve fibers within the VNs with cardiovascular and neurologic disease states. Results All 104 VNs contain TH positive (sympathetic) nerve fibers; the mean TH positive areas were 5.47% in right cervical, 3.97% in left cervical, 5.11% in right thoracic, and 4.20% in left thoracic VN. The distribution of TH positive nerve fibers varied from case to case: central, peripheral, or scattered throughout nerve bundles. No statistically significant differences in nerve morphology were seen between diseases in which VNS is considered effective (depression and CHF), and other cardiovascular diseases, or neurodegenerative disease. Conclusion Human VNs contain sympathetic nerve fibers. The sympathetic component within the VN could play a role in physiologic effects reported with VNS. The recognition of sympathetic nerve fibers in the VNs may lead to better understanding of the therapeutic mechanisms of VNS.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationSeki, A., Green, H. R., Lee, T. D., Hong, L., Tan, J., Vinters, H. V., … Fishbein, M. C. (2014). Sympathetic Nerve Fibers in Human Cervical and Thoracic Vagus Nerves. Heart Rhythm : The Official Journal of the Heart Rhythm Society, 11(8), 1411–1417. http://doi.org/10.1016/j.hrthm.2014.04.032en_US
dc.identifier.issn1547-5271en_US
dc.identifier.urihttps://hdl.handle.net/1805/8194
dc.language.isoen_USen_US
dc.publisherElsen_US
dc.relation.isversionof10.1016/j.hrthm.2014.04.032en_US
dc.relation.journalHeart rhythm : the official journal of the Heart Rhythm Societyen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectHeart Failureen_US
dc.subjectpathologyen_US
dc.subjectNerve Fibersen_US
dc.subjectSuperior Cervical Ganglionen_US
dc.subjectVagus Nerveen_US
dc.subjectSympathetic nervesen_US
dc.subjectGanglion cellsen_US
dc.titleSympathetic Nerve Fibers in Human Cervical and Thoracic Vagus Nervesen_US
dc.typeArticleen_US
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