Fluoride Dentifrice Overcomes the Lower Resistance of Fluorotic Enamel to Demineralization
dc.contributor.author | Almeida, L. F. | |
dc.contributor.author | Marín, L. M. | |
dc.contributor.author | Martínez-Mier, E. A. | |
dc.contributor.author | Cury, J. A. | |
dc.contributor.department | Cariology, Operative Dentistry and Dental Public Health, School of Dentistry | en_US |
dc.date.accessioned | 2020-03-02T20:32:22Z | |
dc.date.available | 2020-03-02T20:32:22Z | |
dc.date.issued | 2019 | |
dc.description.abstract | We evaluated if the low resistance of fluorotic enamel to demineralization could be overcome by fluoride dentifrice (FD) treatment. Paired enamel slabs of sound and fluorotic enamel (n = 20/group) from human teeth presenting Thylstrup and Fejerskov index (TF) scores from 0 to 4 were obtained. Half of the anatomic surface of the enamel slabs was isolated and used as a control (baseline) regarding enamel mineralization and fluoride concentration. The slabs were submitted to a pH-cycling model simulating a high cariogenic challenge, and 2×/day they were treated with placebo dentifrice (PD) or FD (1,100 µg F/g, as NaF). After 10 days, the slabs were cut into two halves. Enamel demineralization was evaluated by cross-sectional microhardness in one half, and the fluoride formed (FF) concentration was determined in the other half. For statistical analysis, the data on net demineralization area (ΔΔS) and FF (µg F/g) were grouped into TF0, TF1–2, and TF3–4, and analyzed by two-way ANOVA followed by Tukey’s test (α = 5%). The factors studied were TF (0, 1–2, and 3–4) and dentifrice treatment (PD or FD). The effect of the factors was statistically significant for ΔΔS and FF (p < 0.05). In the PD group, the following pattern for ΔΔS was observed: TF3–4 > TF1–2 > TF0 (p < 0.05); however, the groups did not differ (p > 0.05) when FD was used. Regarding FF, the groups treated with PD did not differ (p > 0.05), but the greatest (p < 0.05) FF concentration was found in group TF3–4 treated with FD. These findings suggest that the higher susceptibility of fluorotic enamel to demineralization lesions is decreased by the use of FD. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Almeida, L. F., Marín, L. M., Martínez-Mier, E. A., & Cury, J. A. (2019). Fluoride Dentifrice Overcomes the Lower Resistance of Fluorotic Enamel to Demineralization. Caries Research, 53(5), 567–575. https://doi.org/10.1159/000499668 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/22214 | |
dc.language.iso | en | en_US |
dc.publisher | Karger | en_US |
dc.relation.isversionof | 10.1159/000499668 | en_US |
dc.relation.journal | Caries Research | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | Author | en_US |
dc.subject | dental caries | en_US |
dc.subject | dental fluorosis | en_US |
dc.subject | dentifrice | en_US |
dc.title | Fluoride Dentifrice Overcomes the Lower Resistance of Fluorotic Enamel to Demineralization | en_US |
dc.type | Article | en_US |