Contraindicated drug–drug interactions associated with oral antimicrobial agents prescribed in the ambulatory care setting in the United States
dc.contributor.author | Eljaaly, Khalid | |
dc.contributor.author | Alshehri, Samah | |
dc.contributor.author | Bhattacharjee, Sandipan | |
dc.contributor.author | Al-Tawfiq, Jaffar A. | |
dc.contributor.author | Patanwala, Asad E. | |
dc.contributor.department | Medicine, School of Medicine | en_US |
dc.date.accessioned | 2018-10-03T18:50:20Z | |
dc.date.available | 2018-10-03T18:50:20Z | |
dc.date.issued | 2018 | |
dc.description.abstract | Objectives Antimicrobial agents are commonly used in ambulatory care settings. Our objective was to examine national-level patterns of contraindications between oral antibacterial or antifungal agents and patients' other oral medications in the US ambulatory care setting. Methods This cross-sectional study included multiple year pooled data (2003–2011) from the National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey (NHAMCS Outpatient Department). Visits by adults (age ≥18 years) in ambulatory settings in the United States who were prescribed oral antibacterial or antifungal agents were evaluated for potential drug–drug interaction (DDI) contraindications. Findings with relative standard error >30% or unweighted sample size <30 were not reported because these were deemed unreliable estimates. Results From 2003 to 2011, there were 1 235 000 outpatient visits (proportion = 0.52%; 95% confidence interval (CI), 0.29–0.74) in which a patient was prescribed an antimicrobial agent associated with a contraindicated DDI. The most prevalent antimicrobials with contraindicated combination among outpatients were simultaneous use of macrolide-containing products (erythromycin or clarithromycin) with statin medication–containing products (simvastatin or lovastatin) (841 864 visits, proportion = 1.91%; 95% CI, 0.96–2.86). The next most common combination was use of fluoroquinolones with antiarrhythmic agents (amiodarone, sotalol, quinidine or procainamide) (365 622 visits, proportion = 0.19%; 95% CI, 0.06–0.32). Conclusions Providers should be aware of potential contraindicated DDIs when prescribing antibiotics, especially macrolides and fluoroquinolones. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Eljaaly, K., Alshehri, S., Bhattacharjee, S., Al-Tawfiq, J. A., & Patanwala, A. E. (2018). Contraindicated drug–drug interactions associated with oral antimicrobial agents prescribed in the ambulatory care setting in the United States. Clinical Microbiology and Infection. https://doi.org/10.1016/j.cmi.2018.08.002 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/17432 | |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.cmi.2018.08.002 | en_US |
dc.relation.journal | Clinical Microbiology and Infection | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | Author | en_US |
dc.subject | ambulatory | en_US |
dc.subject | antibiotic | en_US |
dc.subject | drug interactions | en_US |
dc.title | Contraindicated drug–drug interactions associated with oral antimicrobial agents prescribed in the ambulatory care setting in the United States | en_US |
dc.type | Article | en_US |