Analysis of longitudinal censored semicontinuous data with application to the study of executive dysfunction: the Towers Task
dc.contributor.author | Lourens, Spencer | |
dc.contributor.author | Zhang, Ying | |
dc.contributor.author | Long, Jeffrey D. | |
dc.contributor.author | Paulsen, Jane S. | |
dc.contributor.department | Biostatistics and Health Data Science, School of Medicine | |
dc.date.accessioned | 2024-03-12T08:17:08Z | |
dc.date.available | 2024-03-12T08:17:08Z | |
dc.date.issued | 2017 | |
dc.description.abstract | Executive dysfunction is a deficiency in skills of planning and problem solving that characterizes many neuropsychiatric disorders. The Towers Task is a commonly used measure of planning and problem solving for assessing executive function. Towers Task data are usually zero-inflated and right-censored, and ignoring these features can result in biased inference for the disease characterization of executive dysfunction. In this manuscript, a mixed-effects model for longitudinal censored semicontinuous data is developed for analyzing longitudinal Towers Task data from the PREDICT-HD study. The model is contrasted with current practice and implications for general use are discussed. | |
dc.eprint.version | Author's manuscript | |
dc.identifier.citation | Lourens S, Zhang Y, Long JD, Paulsen JS. Analysis of longitudinal censored semicontinuous data with application to the study of executive dysfunction: The Towers Task. Stat Methods Med Res. 2017;26(2):865-879. doi:10.1177/0962280214560187 | |
dc.identifier.uri | https://hdl.handle.net/1805/39174 | |
dc.language.iso | en_US | |
dc.publisher | Sage | |
dc.relation.isversionof | 10.1177/0962280214560187 | |
dc.relation.journal | Statistical Methods in Medical Research | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | Cognitive neuroscience | |
dc.subject | Huntington disease | |
dc.subject | Mixed-effect model | |
dc.subject | Censored data | |
dc.subject | Semicontinuous data | |
dc.subject | Towers Task | |
dc.title | Analysis of longitudinal censored semicontinuous data with application to the study of executive dysfunction: the Towers Task | |
dc.type | Article |