Conditioned stimuli affect ethanol-seeking by female alcohol-preferring (P) rats: the role of repeated-deprivations, cue-pretreatment, and cue-temporal intervals

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2019-05-16
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American English
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Abstract

Rationale: Evidence indicates drug-paired stimuli can evoke drug-craving leading to drug-seeking and repeated relapse periods can influence drug-seeking behaviors.

Objectives: The present study examined (1) the effect of an interaction between repeated deprivation cycles and excitatory conditioning stimuli (CS +) on ethanol (EtOH)-seeking; (2) the effects of EtOH-paired cue-exposure in a non-drug paired environment on subsequent conditioning in a drug-paired environment; and (3) the temporal effects of conditioned cues on subsequent EtOH-seeking.

Methods: Adult female alcohol-preferring (P) rats were exposed to three conditioned odor cues; CS+ associated with EtOH self-administration, CS- associated with the absence of EtOH (extinction training), and a neutral stimulus (CS0) presented in a neutral non drug-paired environment. The rats underwent 4 deprivation cycles or were Non-Deprived, following extinction they were maintained in a home cage for an EtOH-free period, and then exposed to no cue, CS+, CS-, or CS0 to assess the effect of the conditioned cues on EtOH-seeking behavior.

Results: Repeated deprivations enhanced and prolonged the duration of CS+ effects on EtOH-seeking. Presentation of the CS- in a non-drug paired environment blocked the ability of a CS+ to enhance EtOH-seeking in a drug-paired environment. Presentation of the CS+ or CS- in a non-drug paired environment 2 or 4-hours earlier significantly altered EtOH-seeking.

Conclusion: Results indicated an interaction between repeated deprivation cycles and CS+ resulted in a potentiation of CS+ evoked EtOH-seeking. In addition, a CS- may have therapeutic potential by providing prophylactic protection against relapse behavior in the presence of cues in the drug-using environment.

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Hauser, S. R., Deehan, G. A., Knight, C. P., Waeiss, R. A., Truitt, W. A., Johnson, P. L., Bell, R. L., McBride, W. J., & Rodd, Z. A. (2019). Conditioned stimuli affect ethanol-seeking by female alcohol-preferring (P) rats: The role of repeated-deprivations, cue-pretreatment, and cue-temporal intervals. Psychopharmacology, 236(9), 2835–2846. https://doi.org/10.1007/s00213-019-05264-6
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1432-2072
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Psychopharmacology
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PMC
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