Early-Age Onset Colorectal Neoplasia in Average-Risk Individuals Undergoing Screening Colonoscopy: A Systematic Review and Meta-Analysis
dc.contributor.author | Kolb, Jennifer M. | |
dc.contributor.author | Hu, Junxiao | |
dc.contributor.author | DeSanto, Kristen | |
dc.contributor.author | Gao, Dexiang | |
dc.contributor.author | Singh, Siddharth | |
dc.contributor.author | Imperiale, Thomas | |
dc.contributor.author | Lieberman, David A. | |
dc.contributor.author | Boland, C. Richard | |
dc.contributor.author | Patel, Swati G. | |
dc.contributor.department | Medicine, School of Medicine | en_US |
dc.date.accessioned | 2021-12-28T21:15:36Z | |
dc.date.available | 2021-12-28T21:15:36Z | |
dc.date.issued | 2021-10 | |
dc.description.abstract | Background/Aims Incidence and mortality associated with early age onset colorectal cancer (EAO-CRC) is increasing, prompting professional society recommendations to lower the screening age in average risk individuals. The yield of screening individuals <50 years old is not known. Methods A systematic review of 3 databases from inception through July 2020 was performed in all languages that reported colonoscopy findings in average risk individuals<50 years old. The primary outcomes were EAO colorectal neoplasia (EAO-CRN) and advanced colorectal neoplasia (EAO-aCRN) prevalence. Subgroup analyses were performed based on sex, geographic location, time period, and age including comparison to age 50-59. Generalized linear mixed model with random intercept logistic regression and fixed subgroup effects were performed Results Of 10,123 unique articles, 17 studies published between 2002-2020, including 51,811 average-risk individuals from four continents, were included. The pooled rate of EAO-CRN was 13.7% (95%CI: 0.112-0.168) and EAO-aCRN was 2.2% (95%CI: 0.016-0.031). Prevalence of CRC was .05% (0.00029-0.0008). Rates of EAO-CRN were higher in men compared to women (RR 1.71, 1.49–1.98), and highest in the United States (15.6%:12.2-19.7) compared to Europe (14.9%:6.9-29.3), East Asia (13.4%:10.3-17.2), and the Middle East (9.8%:7.8-12.2)(p=0.04) The rate of EAO-CRN in age 45-49 and 50-59 was 17.8% (14.5-21.6) and 24.8% (19.5-30.8), respectively (p=0.04). The rate of EAO-aCRN in age 45-49 was 3.6% (1.9-6.7) and 4.2% (3.2-5.7), respectively (p=0.69) Conclusions The rate of advanced colorecta neoplasia in individuals age 45-49 was similar to the rate observed in age 50-59, suggesting that expanding screening to this population could yield similar impact on colorectal cancer risk reduction. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Kolb, J. M., Hu, J., DeSanto, K., Gao, D., Singh, S., Imperiale, T., Lieberman, D. A., Boland, C. R., & Patel, S. G. (2021). Early-Age Onset Colorectal Neoplasia in Average-Risk Individuals Undergoing Screening Colonoscopy: A Systematic Review and Meta-Analysis. Gastroenterology, 161(4), 1145-1155.e12. https://doi.org/10.1053/j.gastro.2021.06.006 | en_US |
dc.identifier.issn | 0016-5085 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/27204 | |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1053/j.gastro.2021.06.006 | en_US |
dc.relation.journal | Gastroenterology | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | Author | en_US |
dc.subject | colon cancer screening | en_US |
dc.subject | colon polyp | en_US |
dc.subject | colorectal cancer | en_US |
dc.title | Early-Age Onset Colorectal Neoplasia in Average-Risk Individuals Undergoing Screening Colonoscopy: A Systematic Review and Meta-Analysis | en_US |
dc.type | Article | en_US |