Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells
dc.contributor.author | Priya, Raj | |
dc.contributor.author | Brutkiewicz, Randy R. | |
dc.contributor.department | Microbiology and Immunology, School of Medicine | en_US |
dc.date.accessioned | 2023-04-12T15:32:40Z | |
dc.date.available | 2023-04-12T15:32:40Z | |
dc.date.issued | 2020-12-15 | |
dc.description.abstract | It is unknown whether brain astrocytes and microglia have the capacity to present microbial antigens via the innate immune MR1/MAIT cell axis. We have detected MAIT cells in the normal mouse brain and found that both astrocytes and microglia are MR1+. When we stimulated brain astrocytes and microglia with E. coli, and then co-cultured them with MAIT cells, MR1 surface expression was upregulated and MAIT cells were activated in an antigen-dependent manner. Considering the association of MAIT cells with inflammatory conditions, including those in the CNS, the MR1/MAIT cell axis could be a novel therapeutic target in neuroinflammatory disorders. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Priya R, Brutkiewicz RR. Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells. J Neuroimmunol. 2020;349:577428. doi:10.1016/j.jneuroim.2020.577428 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/32349 | |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.jneuroim.2020.577428 | en_US |
dc.relation.journal | Journal of Neuroimmunology | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Antigen presentation | en_US |
dc.subject | Astrocytes | en_US |
dc.subject | Innate immunity | en_US |
dc.subject | MAIT cells | en_US |
dc.subject | Microglia | en_US |
dc.title | Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells | en_US |
dc.type | Article | en_US |