Activated endothelial cells induce a distinct type of astrocytic reactivity
dc.contributor.author | Taylor, Xavier | |
dc.contributor.author | Cisternas, Pablo | |
dc.contributor.author | Jury, Nur | |
dc.contributor.author | Martinez, Pablo | |
dc.contributor.author | Huang, Xiaoqing | |
dc.contributor.author | You, Yanwen | |
dc.contributor.author | Redding-Ochoa, Javier | |
dc.contributor.author | Vidal, Ruben | |
dc.contributor.author | Zhang, Jie | |
dc.contributor.author | Troncoso, Juan | |
dc.contributor.author | Lasagna-Reeves, Cristian A. | |
dc.contributor.department | Anatomy, Cell Biology and Physiology, School of Medicine | |
dc.date.accessioned | 2023-06-02T14:03:59Z | |
dc.date.available | 2023-06-02T14:03:59Z | |
dc.date.issued | 2022-03-29 | |
dc.description.abstract | Reactive astrogliosis is a universal response of astrocytes to abnormal events and injuries. Studies have shown that proinflammatory microglia can polarize astrocytes (designated A1 astrocytes) toward a neurotoxic phenotype characterized by increased Complement Component 3 (C3) expression. It is still unclear if inflammatory stimuli from other cell types may also be capable of inducing a subset of C3+ neurotoxic astrocytes. Here, we show that a subtype of C3+ neurotoxic astrocytes is induced by activated endothelial cells that is distinct from astrocytes activated by microglia. Furthermore, we show that endothelial-induced astrocytes have upregulated expression of A1 astrocytic genes and exhibit a distinctive extracellular matrix remodeling profile. Finally, we demonstrate that endothelial-induced astrocytes are Decorin-positive and are associated with vascular amyloid deposits but not parenchymal amyloid plaques in mouse models and AD/CAA patients. These findings demonstrate the existence of potentially extensive and subtle functional diversity of C3+-reactive astrocytes. | en_US |
dc.eprint.version | Final published version | en_US |
dc.identifier.citation | Taylor X, Cisternas P, Jury N, et al. Activated endothelial cells induce a distinct type of astrocytic reactivity. Commun Biol. 2022;5(1):282. Published 2022 Mar 29. doi:10.1038/s42003-022-03237-8 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/33429 | |
dc.language.iso | en_US | en_US |
dc.publisher | Springer Nature | en_US |
dc.relation.isversionof | 10.1038/s42003-022-03237-8 | en_US |
dc.relation.journal | Communications Biology | en_US |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.source | PMC | en_US |
dc.subject | Astrocytes | en_US |
dc.subject | Endothelial cells | en_US |
dc.subject | Microglia | en_US |
dc.title | Activated endothelial cells induce a distinct type of astrocytic reactivity | en_US |
dc.type | Article | en_US |