Histologic and Clinical Follow-up of Thyroid Fine Needle Aspirates in Pediatric Patients
dc.contributor.author | Partyka, Kristen | |
dc.contributor.author | Huang, Eric C. | |
dc.contributor.author | Cramer, Harvey | |
dc.contributor.author | Chen, Shaoxiong | |
dc.contributor.author | Wu, Howard H. | |
dc.contributor.department | Department of Pathology and Laboratory Medicine, IU School of Medicine | en_US |
dc.date.accessioned | 2016-10-28T15:42:09Z | |
dc.date.available | 2016-10-28T15:42:09Z | |
dc.date.issued | 2016-07 | |
dc.description.abstract | BACKGROUND Although fine-needle aspiration (FNA) has an important role in evaluating thyroid nodules in adults, there is little published information regarding its utility in the pediatric population. METHODS A retrospective analysis of thyroid FNAs for patients who were 18 years old or younger at 2 institutions was conducted. Aspirates were retrospectively categorized with the Bethesda System for Reporting Thyroid Cytopathology. These diagnoses were then correlated with either final histopathology or clinical follow-up. RESULTS A total of 186 thyroid FNA samples from 154 patients (122 females and 32 males), who ranged in age from 9 months to 18 years (median, 16 years; mean, 14 years), were identified. FNA was performed to evaluate 1 to 3 nodules for each patient. Aspirates were classified as follows: nondiagnostic (n = 27), benign (n = 114), atypia of undetermined significance (AUS; n = 21), follicular neoplasm (FN; n = 8), suspicious for malignancy (n = 3), and malignant (n = 13). Sixty-one samples had a histologic correlation, 68 were followed clinically for ≥2 years, and 57 either had no follow-up or were followed for <2 years. For statistical purposes, FNA diagnoses of suspicious and malignant were considered positive, and benign lesions were considered negative. The accuracy was 99%, and the sensitivity and specificity were 94% and 100%, respectively. The risk of malignancy, not including papillary microcarcinoma, was 2% for benign aspirates, 21% for AUS, 57% for FN, and 100% for suspicious or malignant aspirates. CONCLUSIONS This analysis demonstrates that FNA is a sensitive and highly specific modality for evaluating thyroid nodules in pediatric patients. Each diagnostic category can facilitate communication and guide appropriate management. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Partyka, K. L., Huang, E. C., Cramer, H. M., Chen, S., & Wu, H. H. (2016). Histologic and clinical follow‐up of thyroid fine‐needle aspirates in pediatric patients. Cancer Cytopathology, 124(7), 467–471. http://doi.org/10.1002/cncy.21713 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/11282 | |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.relation.isversionof | 10.1002/cncy.21713 | en_US |
dc.relation.journal | Cancer Cytopathology | en_US |
dc.rights | IUPUI Open Access Policy | en_US |
dc.source | Author | en_US |
dc.subject | thyroid | en_US |
dc.subject | FNA | en_US |
dc.subject | cytology | en_US |
dc.title | Histologic and Clinical Follow-up of Thyroid Fine Needle Aspirates in Pediatric Patients | en_US |
dc.type | Article | en_US |