Dissecting the Spectrum of Stroke Risk Factors in an Apparently Healthy Population: Paving the Roadmap to Primary Stroke Prevention

dc.contributor.authorEfremova, Daniela
dc.contributor.authorCiolac, Dumitru
dc.contributor.authorZota, Eremei
dc.contributor.authorGlavan, Danu
dc.contributor.authorCiobanu, Natalia
dc.contributor.authorAulitzky, Wolfgang
dc.contributor.authorNics, Anna Maria
dc.contributor.authorTrinka, Eugen
dc.contributor.authorYamada, Chiaki
dc.contributor.authorMovila, Alexandru
dc.contributor.authorGroppa, Stanislav A.
dc.contributor.departmentBiomedical Sciences and Comprehensive Care, School of Dentistry
dc.date.accessioned2023-10-24T19:19:33Z
dc.date.available2023-10-24T19:19:33Z
dc.date.issued2023-01-20
dc.description.abstractWe aimed to investigate, for the first time, the spectrum of stroke risk factors specific to the population of the Republic of Moldova. The subjects were examined according to a pre-established protocol of risk factor estimation. The study involved 300 subjects, including 60% women and 40% men, with a mean age of 49.9 ± 14.5 years. The most common risk factor was abdominal obesity, identified in 75% of subjects; general obesity was detected in 48%, while 32% of subjects were overweight and 20% were normally weighted. Hypertension was observed in 44%; 8% of those examined had atrial fibrillation, and 9% had diabetes mellitus. Left myocardial hypertrophy on ECG was present in 53% of subjects, and acute ischemic changes in 2%. Laboratory observations detected that glycosylated hemoglobin increased by 7%, and >50% had dyslipidemia. Total cholesterol was significantly elevated by 58%, LDL-cholesterol was increased by 32%, and HDL-cholesterol was decreased by 9%. Homocysteine was increased in 55% and high-sensitivity C-reactive protein in 28% of subjects. These results indicate the presence of modifiable risk factors and the necessity to elaborate on the primary prevention strategies aimed at minimizing the burden of stroke in the population of the Republic of Moldova.
dc.eprint.versionFinal published version
dc.identifier.citationEfremova D, Ciolac D, Zota E, et al. Dissecting the Spectrum of Stroke Risk Factors in an Apparently Healthy Population: Paving the Roadmap to Primary Stroke Prevention. J Cardiovasc Dev Dis. 2023;10(2):35. Published 2023 Jan 20. doi:10.3390/jcdd10020035
dc.identifier.urihttps://hdl.handle.net/1805/36622
dc.language.isoen_US
dc.publisherMDPI
dc.relation.isversionof10.3390/jcdd10020035
dc.relation.journalJournal of Cardiovascular Development and Disease
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.sourcePMC
dc.subjectCerebrovascular disease
dc.subjectRisk factors
dc.subjectEpidemiology
dc.subjectPrevention
dc.titleDissecting the Spectrum of Stroke Risk Factors in an Apparently Healthy Population: Paving the Roadmap to Primary Stroke Prevention
dc.typeArticle
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