Sex and Gender Differences in Face and Upper Extremity Allotransplantation: A Narrative Review of Implications and Impact

Abstract

Sex and gender differences play a significant role in vascularized composite allotransplantation (VCA), impacting both surgical outcomes and postoperative care. While sex refers to biological distinctions and gender encompasses life experiences and behaviors, both factors are closely interrelated in transplantation. Biological sex differences, such as immune responses, hormonal fluctuations, and anatomical features influence graft adaptation and healing, while both sex and gender-specific factors affect psychological and functional recovery. Studies indicate that men have higher mortality and reoperation rates, whereas women are more susceptible to adverse effects from immunosuppressive therapies. Unlike solid organ transplantation (SOT), which is primarily lifesaving, VCA focuses on life-enhancing outcomes, requiring careful attention to patients' social, psychological, and functional well-being. Lifelong immunosuppression in VCA carries risks, including infections and cancer, complicating patient management. Psychological readiness is crucial for candidate selection and long-term success, with women often expressing greater concerns about outcomes. Although no significant gender differences in functional recovery have been observed, individualized rehabilitation plans based on anatomical and physiological differences remain essential for optimal recovery.