Inhibiting HDAC for human hematopoietic stem cell expansion
dc.contributor.author | Broxmeyer, Hal E. | |
dc.contributor.department | Department of Microbiology and Immunology, IU School of Medicine | en_US |
dc.date.accessioned | 2016-05-06T16:35:30Z | |
dc.date.available | 2016-05-06T16:35:30Z | |
dc.date.issued | 2014-06 | |
dc.description.abstract | In this issue of the JCI, Chaurasia and colleagues report an impressive ex vivo expansion of HSCs from human cord blood (CB) using cytokines and altering epigenetic modifications. The application of this protocol provides information that has potential for clinical consideration. The enhanced expansion of CB HSCs is a substantial advance over recent work from the Chaurasia and Hoffman group, in which ex vivo production of human erythroid progenitor cells from CB was promoted by chromatin modification. Moreover, this study takes advantage of information from the rapidly emerging, but not yet fully elucidated, field of epigenetics. | en_US |
dc.eprint.version | Final published version | en_US |
dc.identifier.citation | Broxmeyer, H. E. (2014). Inhibiting HDAC for human hematopoietic stem cell expansion. The Journal of Clinical Investigation, 124(6), 2365–2368. http://doi.org/10.1172/JCI75803 | en_US |
dc.identifier.issn | 1558-8238 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/9550 | |
dc.language.iso | en_US | en_US |
dc.publisher | American Society for Clinical Investigation | en_US |
dc.relation.isversionof | 10.1172/JCI75803 | en_US |
dc.relation.journal | The Journal of Clinical Investigation | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Epigenesis, Genetic | en_US |
dc.subject | Fetal Blood | en_US |
dc.subject | cytology | en_US |
dc.subject | metabolism | en_US |
dc.subject | Hematopoietic Stem Cells | en_US |
dc.title | Inhibiting HDAC for human hematopoietic stem cell expansion | en_US |
dc.type | Article | en_US |
ul.alternative.fulltext | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089465/ | en_US |
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