Mechanisms of osteolytic and osteoblastic skeletal lesions.

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dc.contributor.authorDavid Roodman, G.
dc.contributor.authorSilbermann, Rebecca
dc.contributor.departmentDepartment of Medicine, IU School of Medicineen_US
dc.date.accessioned2016-12-15T22:29:47Z
dc.date.available2016-12-15T22:29:47Z
dc.date.issued2015
dc.description.abstractThe bone is a frequent site for tumor metastasis, and cancer in the bone results in marked disturbances of bone remodeling that can be lytic, blastic or a combination of the two. Patients with advanced malignancies that have metastasized to the bone frequently suffer from debilitating skeletal-related events, including pathologic fractures, spinal cord compression syndromes, disorders of calcium and phosphate homeostasis and severe cancer-related pain. This review will discuss recent studies on the mechanisms responsible for osteolytic and osteoblastic metastasis and how their identification has resulted in the development of new agents for patients with metastatic bone disease.en_US
dc.eprint.versionPublished versionen_US
dc.identifier.citationDavid Roodman, G., & Silbermann, R. (2015). Mechanisms of osteolytic and osteoblastic skeletal lesions. BoneKEy Reports, 4, 753. https://doi.org/10.1038/bonekey.2015.122en_US
dc.identifier.issn2047-6396en_US
dc.identifier.urihttps://hdl.handle.net/1805/11621
dc.language.isoen_USen_US
dc.publisherNatureen_US
dc.relation.isversionof10.1038/bonekey.2015.122en_US
dc.relation.journalBoneKEy Reportsen_US
dc.rightsPublisher's Policyen_US
dc.sourcePMCen_US
dc.subjectCanceren_US
dc.subjectBone Tumorsen_US
dc.subjectMetastasisen_US
dc.titleMechanisms of osteolytic and osteoblastic skeletal lesions.en_US
dc.typeArticleen_US
ul.alternative.fulltexthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625391/en_US
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