The Difference in Translaminar Pressure Gradient and Neuroretinal Rim Area in Glaucoma and Healthy Subjects

dc.contributor.authorSiaudvytyte, Lina
dc.contributor.authorJanuleviciene, Ingrida
dc.contributor.authorRagauskas, Arminas
dc.contributor.authorBartusis, Laimonas
dc.contributor.authorMeiliuniene, Indre
dc.contributor.authorSiesky, Brent
dc.contributor.authorHarris, Alon
dc.contributor.departmentOphthalmology, School of Medicine
dc.date.accessioned2025-04-03T14:15:29Z
dc.date.available2025-04-03T14:15:29Z
dc.date.issued2014
dc.description.abstractPurpose: To assess differences in translaminar pressure gradient (TPG) and neuroretinal rim area (NRA) in patients with normal tension glaucoma (NTG), high tension glaucoma (HTG), and healthy controls. Methods: 27 patients with NTG, HTG, and healthy controls were included in the prospective pilot study (each group consisted of 9 patients). Intraocular pressure (IOP), intracranial pressure (ICP), and confocal laser scanning tomography were assessed. TPG was calculated as the difference of IOP minus ICP. ICP was measured using noninvasive two-depth transcranial Doppler device. The level of significance P < 0.05 was considered significant. Results: NTG patients had significantly lower IOP (13.7(1.6) mmHg), NRA (0.97(0.36) mm(2)), comparing with HTG and healthy subjects, P < 0.05. ICP was lower in NTG (7.4(2.7) mmHg), compared with HTG (8.9(1.9) mmHg) and healthy subjects (10.5(3.0) mmHg); however, the difference between groups was not statistically significant (P > 0.05). The difference between TPG for healthy (5.4(7.7) mmHg) and glaucomatous eyes (NTG 6.3(3.1) mmHg, HTG 15.7(7.7) mmHg) was statistically significant (P < 0.001). Higher TPG was correlated with decreased NRA (r = -0.83; P = 0.01) in the NTG group. Conclusion: Translaminar pressure gradient was higher in glaucoma patients. Reduction of NRA was related to higher TPG in NTG patients. Further prospective studies are warranted to investigate the involvement of TPG in glaucoma management.
dc.eprint.versionFinal published version
dc.identifier.citationSiaudvytyte L, Januleviciene I, Ragauskas A, et al. The difference in translaminar pressure gradient and neuroretinal rim area in glaucoma and healthy subjects. J Ophthalmol. 2014;2014:937360. doi:10.1155/2014/937360
dc.identifier.urihttps://hdl.handle.net/1805/46804
dc.language.isoen_US
dc.publisherHindawi
dc.relation.isversionof10.1155/2014/937360
dc.relation.journalJournal of Ophthalmology
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePMC
dc.subjectTranslaminar pressure gradient (TPG)
dc.subjectNeuroretinal rim area (NRA)
dc.subjectNormal tension glaucoma (NTG)
dc.subjectHigh tension glaucoma (HTG)
dc.titleThe Difference in Translaminar Pressure Gradient and Neuroretinal Rim Area in Glaucoma and Healthy Subjects
dc.typeArticle
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