Evidence for BCR/ABL1‐positive T‐cell acute lymphoblastic leukemia arising in an early lymphoid progenitor cell
dc.contributor.author | Ragg, Susanne | |
dc.contributor.author | Zehentner, Barbara K. | |
dc.contributor.author | Loken, Michael R. | |
dc.contributor.author | Croop, James M. | |
dc.contributor.department | Pediatrics, School of Medicine | en_US |
dc.date.accessioned | 2020-02-11T16:41:15Z | |
dc.date.available | 2020-02-11T16:41:15Z | |
dc.date.issued | 2019-09 | |
dc.description.abstract | BCR‐ABL1‐positive leukemias have historically been classified as either chronic myelogenous leukemia or Ph+ acute lymphoblastic leukemia. Recent analyses suggest there may be a wider range of subtypes. We report a patient with BCR‐ABL1 fusion positive T‐cell ALL with a previously undescribed cell distribution of the fusion gene. The examination of sorted cells by fluorescence in situ hybridization showed the BCR‐ABL1 fusion in the malignant T cells and a subpopulation of the nonmalignant B cells, but not nonmalignant T cells or myeloid or CD34+ progenitor cells providing evidence that the fusion may have occurred in an early lymphoid progenitor. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Ragg, S., Zehentner, B. K., Loken, M. R., & Croop, J. M. (2019). Evidence for BCR/ABL1-positive T-cell acute lymphoblastic leukemia arising in an early lymphoid progenitor cell. Pediatric Blood & Cancer, 66(9), e27829. https://doi.org/10.1002/pbc.27829 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/22050 | |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.relation.isversionof | 10.1002/pbc.27829 | en_US |
dc.relation.journal | Pediatric Blood & Cancer | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | Author | en_US |
dc.subject | BCR-ABL1 | en_US |
dc.subject | discordant MRD | en_US |
dc.subject | T‐cell ALL | en_US |
dc.title | Evidence for BCR/ABL1‐positive T‐cell acute lymphoblastic leukemia arising in an early lymphoid progenitor cell | en_US |
dc.type | Article | en_US |