NaF-PET Imaging of Atherosclerosis Burden

dc.contributor.authorHøilund-Carlsen, Poul F.
dc.contributor.authorPiri, Reza
dc.contributor.authorGerke, Oke
dc.contributor.authorSturek, Michael
dc.contributor.authorWerner, Thomas J.
dc.contributor.authorRevheim, Mona-Elisabeth
dc.contributor.authorAlavi, Abass
dc.contributor.departmentAnatomy, Cell Biology and Physiology, School of Medicine
dc.date.accessioned2023-10-25T12:46:15Z
dc.date.available2023-10-25T12:46:15Z
dc.date.issued2023-01-30
dc.description.abstractThe method of 18F-sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) of atherosclerosis was introduced 12 years ago. This approach is particularly interesting because it demonstrates microcalcification as an incipient sign of atherosclerosis before the development of arterial wall macrocalcification detectable by CT. However, this method has not yet found its place in the clinical routine. The more exact association between NaF uptake and future arterial calcification is not fully understood, and it remains unclear to what extent NaF-PET may replace or significantly improve clinical cardiovascular risk scoring. The first 10 years of publications in the field were characterized by heterogeneity at multiple levels, and it is not clear how the method may contribute to triage and management of patients with atherosclerosis, including monitoring effects of anti-atherosclerosis intervention. The present review summarizes findings from the recent 2¾ years including the ability of NaF-PET imaging to assess disease progress and evaluate response to treatment. Despite valuable new information, pertinent questions remain unanswered, not least due to a pronounced lack of standardization within the field and of well-designed long-term studies illuminating the natural history of atherosclerosis and effects of intervention.
dc.eprint.versionFinal published version
dc.identifier.citationHøilund-Carlsen PF, Piri R, Gerke O, et al. NaF-PET Imaging of Atherosclerosis Burden. J Imaging. 2023;9(2):31. Published 2023 Jan 30. doi:10.3390/jimaging9020031
dc.identifier.urihttps://hdl.handle.net/1805/36645
dc.language.isoen_US
dc.publisherMDPI
dc.relation.isversionof10.3390/jimaging9020031
dc.relation.journalJournal of Imaging
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePMC
dc.subjectAtherosclerosis
dc.subjectDisease progression
dc.subject18F-sodium fluoride
dc.subjectIntervention
dc.subjectNaF
dc.subjectPET/CT
dc.titleNaF-PET Imaging of Atherosclerosis Burden
dc.typeArticle
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