Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine

dc.contributor.authorTobias, Deirdre K.
dc.contributor.authorMerino, Jordi
dc.contributor.authorAhmad, Abrar
dc.contributor.authorAiken, Catherine
dc.contributor.authorBenham, Jamie L.
dc.contributor.authorBodhini, Dhanasekaran
dc.contributor.authorClark, Amy L.
dc.contributor.authorColclough, Kevin
dc.contributor.authorCorcoy, Rosa
dc.contributor.authorCromer, Sara J.
dc.contributor.authorDuan, Daisy
dc.contributor.authorFelton, Jamie L.
dc.contributor.authorFrancis, Ellen C.
dc.contributor.authorGillard, Pieter
dc.contributor.authorGingras, Véronique
dc.contributor.authorGaillard, Romy
dc.contributor.authorHaider, Eram
dc.contributor.authorHughes, Alice
dc.contributor.authorIkle, Jennifer M.
dc.contributor.authorJacobsen, Laura M.
dc.contributor.authorKahkoska, Anna R.
dc.contributor.authorKettunen, Jarno L. T.
dc.contributor.authorKreienkamp, Raymond J.
dc.contributor.authorLim, Lee-Ling
dc.contributor.authorMännistö, Jonna M. E.
dc.contributor.authorMassey, Robert
dc.contributor.authorMclennan, Niamh-Maire
dc.contributor.authorMiller, Rachel G.
dc.contributor.authorMorieri, Mario Luca
dc.contributor.authorMost, Jasper
dc.contributor.authorNaylor, Rochelle N.
dc.contributor.authorOzkan, Bige
dc.contributor.authorPatel, Kashyap Amratlal
dc.contributor.authorPilla, Scott J.
dc.contributor.authorPrystupa, Katsiaryna
dc.contributor.authorRaghavan, Sridharan
dc.contributor.authorRooney, Mary R.
dc.contributor.authorSchön, Martin
dc.contributor.authorSemnani-Azad, Zhila
dc.contributor.authorSevilla-Gonzalez, Magdalena
dc.contributor.authorSvalastoga, Pernille
dc.contributor.authorTakele, Wubet Worku
dc.contributor.authorTam, Claudia Ha-Ting
dc.contributor.authorThuesen, Anne Cathrine B.
dc.contributor.authorTosur, Mustafa
dc.contributor.authorWallace, Amelia S.
dc.contributor.authorWang, Caroline C.
dc.contributor.authorWong, Jessie J.
dc.contributor.authorYamamoto, Jennifer M.
dc.contributor.authorYoung, Katherine
dc.contributor.authorAmouyal, Chloé
dc.contributor.authorAndersen, Mette K.
dc.contributor.authorBonham, Maxine P.
dc.contributor.authorChen, Mingling
dc.contributor.authorCheng, Feifei
dc.contributor.authorChikowore, Tinashe
dc.contributor.authorChivers, Sian C.
dc.contributor.authorClemmensen, Christoffer
dc.contributor.authorDabelea, Dana
dc.contributor.authorDawed, Adem Y.
dc.contributor.authorDeutsch, Aaron J.
dc.contributor.authorDickens, Laura T.
dc.contributor.authorDiMeglio, Linda A.
dc.contributor.authorDudenhöffer-Pfeifer, Monika
dc.contributor.authorEvans-Molina, Carmella
dc.contributor.authorFernández-Balsells, María Mercè
dc.contributor.authorFitipaldi, Hugo
dc.contributor.authorFitzpatrick, Stephanie L.
dc.contributor.authorGitelman, Stephen E.
dc.contributor.authorGoodarzi, Mark O.
dc.contributor.authorGrieger, Jessica A.
dc.contributor.authorGuasch-Ferré, Marta
dc.contributor.authorHabibi, Nahal
dc.contributor.authorHansen, Torben
dc.contributor.authorHuang, Chuiguo
dc.contributor.authorHarris-Kawano, Arianna
dc.contributor.authorIsmail, Heba M.
dc.contributor.authorHoag, Benjamin
dc.contributor.authorJohnson, Randi K.
dc.contributor.authorJones, Angus G.
dc.contributor.authorKoivula, Robert W.
dc.contributor.authorLeong, Aaron
dc.contributor.authorLeung, Gloria K. W.
dc.contributor.authorLibman, Ingrid M.
dc.contributor.authorLiu, Kai
dc.contributor.authorLong, S. Alice
dc.contributor.authorLowe, William L., Jr.
dc.contributor.authorMorton, Robert W.
dc.contributor.authorMotala, Ayesha A.
dc.contributor.authorOnengut-Gumuscu, Suna
dc.contributor.authorPankow, James S.
dc.contributor.authorPathirana, Maleesa
dc.contributor.authorPazmino, Sofia
dc.contributor.authorPerez, Dianna
dc.contributor.authorPetrie, John R.
dc.contributor.authorPowe, Camille E.
dc.contributor.authorQuinteros, Alejandra
dc.contributor.authorJain, Rashmi
dc.contributor.authorRay, Debashree
dc.contributor.authorRied-Larsen, Mathias
dc.contributor.authorSaeed, Zeb
dc.contributor.authorSanthakumar, Vanessa
dc.contributor.authorKanbour, Sarah
dc.contributor.authorSarkar, Sudipa
dc.contributor.authorMonaco, Gabriela S. F.
dc.contributor.authorScholtens, Denise M.
dc.contributor.authorSelvin, Elizabeth
dc.contributor.authorSheu, Wayne Huey-Herng
dc.contributor.authorSpeake, Cate
dc.contributor.authorStanislawski, Maggie A.
dc.contributor.authorSteenackers, Nele
dc.contributor.authorSteck, Andrea K.
dc.contributor.authorStefan, Norbert
dc.contributor.authorStøy, Julie
dc.contributor.authorTaylor, Rachael
dc.contributor.authorTye, Sok Cin
dc.contributor.authorUkke, Gebresilasea Gendisha
dc.contributor.authorUrazbayeva, Marzhan
dc.contributor.authorVan der Schueren, Bart
dc.contributor.authorVatier, Camille
dc.contributor.authorWentworth, John M.
dc.contributor.authorHannah, Wesley
dc.contributor.authorWhite, Sara L.
dc.contributor.authorYu, Gechang
dc.contributor.authorZhang, Yingchai
dc.contributor.authorZhou, Shao J.
dc.contributor.authorBeltrand, Jacques
dc.contributor.authorPolak, Michel
dc.contributor.authorAukrust, Ingvild
dc.contributor.authorde Franco, Elisa
dc.contributor.authorFlanagan, Sarah E.
dc.contributor.authorMaloney, Kristin A.
dc.contributor.authorMcGovern, Andrew
dc.contributor.authorMolnes, Janne
dc.contributor.authorNakabuye, Mariam
dc.contributor.authorNjølstad, Pål Rasmus
dc.contributor.authorPomares-Millan, Hugo
dc.contributor.authorProvenzano, Michele
dc.contributor.authorSaint-Martin, Cécile
dc.contributor.authorZhang, Cuilin
dc.contributor.authorZhu, Yeyi
dc.contributor.authorAuh, Sungyoung
dc.contributor.authorde Souza, Russell
dc.contributor.authorFawcett, Andrea J.
dc.contributor.authorGruber, Chandra
dc.contributor.authorMekonnen, Eskedar Getie
dc.contributor.authorMixter, Emily
dc.contributor.authorSherifali, Diana
dc.contributor.authorEckel, Robert H.
dc.contributor.authorNolan, John J.
dc.contributor.authorPhilipson, Louis H.
dc.contributor.authorBrown, Rebecca J.
dc.contributor.authorBillings, Liana K.
dc.contributor.authorBoyle, Kristen
dc.contributor.authorCostacou, Tina
dc.contributor.authorDennis, John M.
dc.contributor.authorFlorez, Jose C.
dc.contributor.authorGloyn, Anna L.
dc.contributor.authorGomez, Maria F.
dc.contributor.authorGottlieb, Peter A.
dc.contributor.authorGreeley, Siri Atma W.
dc.contributor.authorGriffin, Kurt
dc.contributor.authorHattersley, Andrew T.
dc.contributor.authorHirsch, Irl B.
dc.contributor.authorHivert, Marie-France
dc.contributor.authorHood, Korey K.
dc.contributor.authorJosefson, Jami L.
dc.contributor.authorKwak, Soo Heon
dc.contributor.authorLaffel, Lori M.
dc.contributor.authorLim, Siew S.
dc.contributor.authorLoos, Ruth J. F.
dc.contributor.authorMa, Ronald C. W.
dc.contributor.authorMathieu, Chantal
dc.contributor.authorMathioudakis, Nestoras
dc.contributor.authorMeigs, James B.
dc.contributor.authorMisra, Shivani
dc.contributor.authorMohan, Viswanathan
dc.contributor.authorMurphy, Rinki
dc.contributor.authorOram, Richard
dc.contributor.authorOwen, Katharine R.
dc.contributor.authorOzanne, Susan E.
dc.contributor.authorPearson, Ewan R.
dc.contributor.authorPerng, Wei
dc.contributor.authorPollin, Toni I.
dc.contributor.authorPop-Busui, Rodica
dc.contributor.authorPratley, Richard E.
dc.contributor.authorRedman, Leanne M.
dc.contributor.authorRedondo, Maria J.
dc.contributor.authorReynolds, Rebecca M.
dc.contributor.authorSemple, Robert K.
dc.contributor.authorSherr, Jennifer L.
dc.contributor.authorSims, Emily K.
dc.contributor.authorSweeting, Arianne
dc.contributor.authorTuomi, Tiinamaija
dc.contributor.authorUdler, Miriam S.
dc.contributor.authorVesco, Kimberly K.
dc.contributor.authorVilsbøll, Tina
dc.contributor.authorWagner, Robert
dc.contributor.authorRich, Stephen S.
dc.contributor.authorFranks, Paul W.
dc.contributor.departmentPediatrics, School of Medicine
dc.date.accessioned2024-07-16T13:26:27Z
dc.date.available2024-07-16T13:26:27Z
dc.date.issued2023
dc.description.abstractPrecision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationTobias DK, Merino J, Ahmad A, et al. Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine. Nat Med. 2023;29(10):2438-2457. doi:10.1038/s41591-023-02502-5
dc.identifier.urihttps://hdl.handle.net/1805/42250
dc.language.isoen_US
dc.publisherSpringer Nature
dc.relation.isversionof10.1038/s41591-023-02502-5
dc.relation.journalNature Medicine
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectDiabetes mellitus
dc.subjectEvidence-based medicine
dc.subjectPrecision medicine
dc.subjectConsensus
dc.titleSecond international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine
dc.typeArticle
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