Retinoic acid deficiency impairs the vestibular function

dc.contributor.authorRomand, Raymond
dc.contributor.authorKrezel, Wojciech
dc.contributor.authorBeraneck, Mathieu
dc.contributor.authorCammas, Laura
dc.contributor.authorFraulob, Valérie
dc.contributor.authorMessaddeq, Nadia
dc.contributor.authorKessler, Pascal
dc.contributor.authorHashino, Eri
dc.contributor.authorDollé, Pascal
dc.contributor.departmentOtolaryngology -- Head and Neck Surgery, School of Medicineen_US
dc.date.accessioned2019-10-17T18:36:12Z
dc.date.available2019-10-17T18:36:12Z
dc.date.issued2013-03-27
dc.description.abstractThe retinaldehyde dehydrogenase 3 (Raldh3) gene encodes a major retinoic acid synthesizing enzyme and is highly expressed in the inner ear during embryogenesis. We found that mice deficient in Raldh3 bear severe impairment in vestibular functions. These mutant mice exhibited spontaneous circling/tilted behaviors and performed poorly in several vestibular-motor function tests. In addition, video-oculography revealed a complete loss of the maculo-ocular reflex and a significant reduction in the horizontal angular vestibulo-ocular reflex, indicating that detection of both linear acceleration and angular rotation were compromised in the mutants. Consistent with these behavioral and functional deficiencies, morphological anomalies, characterized by a smaller vestibular organ with thinner semicircular canals and a significant reduction in the number of otoconia in the saccule and the utricle, were consistently observed in the Raldh3 mutants. The loss of otoconia in the mutants may be attributed, at least in part, to significantly reduced expression of Otop1, which encodes a protein known to be involved in calcium regulation in the otolithic organs. Our data thus reveal a previously unrecognized role of Raldh3 in structural and functional development of the vestibular end organs.en_US
dc.identifier.citationRomand, R., Krezel, W., Beraneck, M., Cammas, L., Fraulob, V., Messaddeq, N., … Dollé, P. (2013). Retinoic acid deficiency impairs the vestibular function. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(13), 5856–5866. doi:10.1523/JNEUROSCI.4618-12.2013en_US
dc.identifier.urihttps://hdl.handle.net/1805/21184
dc.language.isoen_USen_US
dc.publisherSociety for Neuroscienceen_US
dc.relation.isversionof10.1523/JNEUROSCI.4618-12.2013en_US
dc.relation.journalThe Journal of Neuroscienceen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectBehavioral symptomsen_US
dc.subjectGene Expression Regulation, Developmentalen_US
dc.subjectMotor activityen_US
dc.subjectReflex, Vestibulo-Ocularen_US
dc.subjectVestibule, Labyrinthen_US
dc.subjectVitamin A deficiencyen_US
dc.titleRetinoic acid deficiency impairs the vestibular functionen_US
dc.typeArticleen_US
ul.alternative.fulltexthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705067/en_US
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