Effects of oxycodone pharmacogenetics on postoperative analgesia and related clinical outcomes in children: a pilot prospective study

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dc.contributor.authorAruldhas, Blessed W.
dc.contributor.authorQuinney, Sara K.
dc.contributor.authorPackiasabapathy, Senthil
dc.contributor.authorOverholser, Brian R.
dc.contributor.authorRaymond, Olivia
dc.contributor.authorSivam, Sahana
dc.contributor.authorSivam, Inesh
dc.contributor.authorVelu, Sanjana
dc.contributor.authorMontelibano, Antoinette
dc.contributor.authorSadhasivam, Senthilkumar
dc.contributor.departmentMedicine, School of Medicine
dc.date.accessioned2024-06-25T14:28:29Z
dc.date.available2024-06-25T14:28:29Z
dc.date.issued2023
dc.description.abstractBackground: Variability in the pharmacokinetics and pharmacodynamics of oxycodone in children undergoing surgery could be due to genetic polymorphisms. Materials & methods: The authors studied the association between clinical outcomes and pharmacogenes in children undergoing major surgery. A total of 89 children (35 undergoing pectus excavatum repair and 54 undergoing spinal fusion) were recruited. Results: OPRM1 SNP rs6902403 showed an association with maximum pain score and total morphine equivalent dose (p < 0.05). Other polymorphisms in OPRM1 SNP, PXR, COMT and ABCB1 were also shown to be associated with average morphine equivalent dose, length of hospital stay and maximum surgical pain (p < 0.05). Conclusion: This study demonstrates novel associations between the above pharmacogenes and oxycodone's pharmacokinetics as well as postoperative outcomes in children.
dc.eprint.versionFinal published version
dc.identifier.citationAruldhas BW, Quinney SK, Packiasabapathy S, et al. Effects of oxycodone pharmacogenetics on postoperative analgesia and related clinical outcomes in children: a pilot prospective study. Pharmacogenomics. 2023;24(4):187-197. doi:10.2217/pgs-2022-0149
dc.identifier.urihttps://hdl.handle.net/1805/41877
dc.language.isoen_US
dc.publisherTaylor & Francis
dc.relation.isversionof10.2217/pgs-2022-0149
dc.relation.journalPharmacogenomics
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectABCB1
dc.subjectAnalgesia
dc.subjectChildren
dc.subjectHospital stay
dc.subjectOxycodone
dc.subjectPharmacogenetics
dc.subjectPharmacokinetics
dc.titleEffects of oxycodone pharmacogenetics on postoperative analgesia and related clinical outcomes in children: a pilot prospective study
dc.typeArticle
ul.alternative.fulltexthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061242/
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