Risk Factors for Multisystem Inflammatory Syndrome in Children: A Case-Control Investigation
dc.contributor.author | Zambrano, Laura D. | |
dc.contributor.author | Wu, Michael J. | |
dc.contributor.author | Martin, Lora | |
dc.contributor.author | Malloch, Lacy | |
dc.contributor.author | Chen, Sabrina | |
dc.contributor.author | Newhams, Margaret M. | |
dc.contributor.author | Kucukak, Suden | |
dc.contributor.author | Son, Mary Beth | |
dc.contributor.author | Sanders, Cameron | |
dc.contributor.author | Patterson, Kayla | |
dc.contributor.author | Halasa, Natasha | |
dc.contributor.author | Fitzgerald, Julie C. | |
dc.contributor.author | Leroue, Matthew K. | |
dc.contributor.author | Hall, Mark | |
dc.contributor.author | Irby, Katherine | |
dc.contributor.author | Rowan, Courtney M. | |
dc.contributor.author | Wellnitz, Kari | |
dc.contributor.author | Sahni, Leila C. | |
dc.contributor.author | Loftis, Laura | |
dc.contributor.author | Bradford, Tamara T. | |
dc.contributor.author | Staat, Mary | |
dc.contributor.author | Babbitt, Christopher | |
dc.contributor.author | Carroll, Christopher L. | |
dc.contributor.author | Pannaraj, Pia S. | |
dc.contributor.author | Kong, Michele | |
dc.contributor.author | Schuster, Jennifer E. | |
dc.contributor.author | Chou, Janet | |
dc.contributor.author | Patel, Manish M. | |
dc.contributor.author | Randolph, Adrienne G. | |
dc.contributor.author | Campbell, Angela P. | |
dc.contributor.author | Hobbs, Charlotte V. | |
dc.contributor.author | Overcoming COVID-19 investigators | |
dc.contributor.department | Pediatrics, School of Medicine | |
dc.date.accessioned | 2024-01-26T14:12:10Z | |
dc.date.available | 2024-01-26T14:12:10Z | |
dc.date.issued | 2023 | |
dc.description.abstract | Background: In a 2020 pilot case-control study using medical records, we reported that non-Hispanic Black children were more likely to develop multisystem inflammatory syndrome in children (MIS-C) after adjustment for sociodemographic factors and underlying medical conditions. Using structured interviews, we investigated patient, household, and community factors underlying MIS-C likelihood. Methods: MIS-C case patients hospitalized in 2021 across 14 US pediatric hospitals were matched by age and site to outpatient controls testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within 3 months of the admission date. Caregiver interviews queried race/ethnicity, medical history, and household and potential community exposures 1 month before MIS-C hospitalization (case-patients) or after SARS-CoV-2 infection (controls). We calculated adjusted odds ratios (aOR) using mixed-effects multivariable logistic regression. Results: Among 275 case patients and 496 controls, race/ethnicity, social vulnerability and patient or family history of autoimmune/rheumatologic disease were not associated with MIS-C. In previously healthy children, MIS-C was associated with a history of hospitalization for an infection [aOR: 4.8; 95% confidence interval (CI): 2.1-11.0]. Household crowding (aOR: 1.7; 95% CI: 1.2-2.6), large event attendance (aOR: 1.7; 95% CI: 1.3-2.1), school attendance with limited masking (aOR: 2.6; 95% CI: 1.1-6.6), public transit use (aOR: 1.8; 95% CI: 1.4-2.4) and co-resident testing positive for SARS-CoV-2 (aOR: 2.2; 95% CI: 1.3-3.7) were associated with increased MIS-C likelihood, with risk increasing with the number of these factors. Conclusions: From caregiver interviews, we clarify household and community exposures associated with MIS-C; however, we did not confirm prior associations between sociodemographic factors and MIS-C. | |
dc.eprint.version | Author's manuscript | |
dc.identifier.citation | Zambrano LD, Wu MJ, Martin L, et al. Risk Factors for Multisystem Inflammatory Syndrome in Children: A Case-control Investigation. Pediatr Infect Dis J. 2023;42(6):e190-e196. doi:10.1097/INF.0000000000003900 | |
dc.identifier.uri | https://hdl.handle.net/1805/38224 | |
dc.language.iso | en_US | |
dc.publisher | Wolters Kluwer | |
dc.relation.isversionof | 10.1097/INF.0000000000003900 | |
dc.relation.journal | The Pediatric Infectious Disease Journal | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | Children | |
dc.subject | Coronavirus disease 2019 (COVID-19) | |
dc.subject | Multisystem inflammatory syndrome in children | |
dc.subject | SARS-CoV-2 | |
dc.subject | Risk factors | |
dc.title | Risk Factors for Multisystem Inflammatory Syndrome in Children: A Case-Control Investigation | |
dc.type | Article |