The Impact of Genomic Profiling for Novel Cancer Therapy–Recent Progress in Non-Small Cell Lung Cancer
dc.contributor.author | Xie, Jingwu | |
dc.contributor.author | Zhang, Xiaoli | |
dc.contributor.department | Department of Pediatrics, IU School of Medicine | en_US |
dc.date.accessioned | 2016-10-07T18:26:05Z | |
dc.date.available | 2016-10-07T18:26:05Z | |
dc.date.issued | 2016-01 | |
dc.description.abstract | There is high expectation for significant improvements in cancer patient care after completion of the human genome project in 2003. Through pains-taking analyses of genomic profiles in cancer patients, a number of targetable gene alterations have been discovered, with some leading to novel therapies, such as activating mutations of EGFR, BRAF and ALK gene fusions. As a result, clinical management of cancer through targeted therapy has finally become a reality for a subset of cancers, such as lung adenocarcinomas and melanomas. In this review, we summarize how gene mutation discovery leads to new treatment strategies using non-small cell lung cancer (NSCLC) as an example. We also discuss possible future implications of cancer genome analyses. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Xie, J., & Zhang, X. (2016). The Impact of Genomic Profiling for Novel Cancer Therapy–Recent Progress in Non-Small Cell Lung Cancer. Journal of Genetics and Genomics, 43(1), 3-10. http://dx.doi.org/10.1016/j.jgg.2015.09.003 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/11152 | |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.jgg.2015.09.003 | en_US |
dc.relation.journal | Journal of Genetics and Genomics | en_US |
dc.rights | IUPUI Open Access Policy | en_US |
dc.source | Author | en_US |
dc.subject | targeted therapy | en_US |
dc.subject | lung cancer | en_US |
dc.subject | gene mutation | en_US |
dc.title | The Impact of Genomic Profiling for Novel Cancer Therapy–Recent Progress in Non-Small Cell Lung Cancer | en_US |
dc.type | Article | en_US |