Expression of gilt acts as a positive regulator of mouse hematopoietic progenitor cells

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dc.contributor.authorBroxmeyer, Hal E.
dc.contributor.authorCooper, Scott
dc.contributor.authorBlum, Janice S.
dc.contributor.departmentMicrobiology and Immunology, School of Medicine
dc.date.accessioned2023-08-28T13:02:46Z
dc.date.available2023-08-28T13:02:46Z
dc.date.issued2021
dc.description.abstractGamma interferon inducible lysosomal thiol reductase (GILT), is known to be involved in immunity, but its role in hematopoiesis has not been previously reported. Herein, we demonstrate using gilt knockout (-/-) mice that loss of gilt associates with decreased numbers and cycling status of femoral hematopoietic progenitor cells (CFU-GM, BFU-E, and CFU-GEMM) with more modest effects on splenic progenitor cells. Thus, GILT is associated with positive regulation of hematopoietic progenitor cells in mice, mainly in bone marrow.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationBroxmeyer HE, Cooper S, Blum JS. Expression of gilt acts as a positive regulator of mouse hematopoietic progenitor cells. Blood Cells Mol Dis. 2021;90:102574. doi:10.1016/j.bcmd.2021.102574
dc.identifier.urihttps://hdl.handle.net/1805/35176
dc.language.isoen_US
dc.publisherElsevier
dc.relation.isversionof10.1016/j.bcmd.2021.102574
dc.relation.journalBlood Cells, Molecules, and Diseases
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectGilt
dc.subjectBone marrow
dc.subjectSpleen
dc.subjectHematopoietic progenitor cells
dc.titleExpression of gilt acts as a positive regulator of mouse hematopoietic progenitor cells
dc.typeArticle
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