Palladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated C(sp3)–H bonds with acetonitrile
| dc.contributor.author | Liu, Yongbing | |
| dc.contributor.author | Yang, Ke | |
| dc.contributor.author | Ge, Haibo | |
| dc.contributor.department | Department of Chemistry & Chemical Biology, School of Science | en_US |
| dc.date.accessioned | 2016-11-02T19:45:47Z | |
| dc.date.available | 2016-11-02T19:45:47Z | |
| dc.date.issued | 2016-04-21 | |
| dc.description.abstract | The direct cyanomethylation of unactivated sp3 C–H bonds of aliphatic amides was achieved via palladium catalysis assisted by a bidentate directing group with good functional group compatibility. This process represents the first example of the direct cross-coupling of sp3 C–H bonds with acetonitrile. Considering the importance of the cyano group in medicinal and synthetic organic chemistry, this reaction will find broad application in chemical research. | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.identifier.citation | Liu, Y., Yang, K., & Ge, H. (2016). Palladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated C (sp 3)–H bonds with acetonitrile. Chemical Science, 7(4), 2804-2808. http://dx.doi.org/10.1039/c5sc04066c | en_US |
| dc.identifier.uri | https://hdl.handle.net/1805/11339 | |
| dc.language.iso | en | en_US |
| dc.publisher | RSC | en_US |
| dc.relation.isversionof | 10.1039/c5sc04066c | en_US |
| dc.relation.journal | Chemical Science | en_US |
| dc.rights | Attribution 3.0 United States | |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | |
| dc.source | Publisher | en_US |
| dc.subject | acetonitrile | en_US |
| dc.subject | cyanomethylation | en_US |
| dc.title | Palladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated C(sp3)–H bonds with acetonitrile | en_US |
| dc.type | Article | en_US |