Apathy and Anxiety are Related to Poor Function in Persons with Early-Onset Alzheimer’s Disease
dc.contributor.author | Crouch, Adele | |
dc.contributor.author | Massimo, Lauren | |
dc.contributor.department | School of Nursing | |
dc.date.accessioned | 2024-04-15T09:14:11Z | |
dc.date.available | 2024-04-15T09:14:11Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Neuropsychiatric symptoms are prevalent in persons with early-onset Alzheimer’s disease (EOAD) and may contribute to the inability to perform instrumental activities of daily living. We examined associations between frequently observed symptoms in persons with EOAD: apathy, anxiety, depression, and patient function. Caregivers of 94 persons with EOAD completed questionnaires including the Neuropsychiatric Inventory and the Functional Activities Questionnaire. Regression analyses were performed for each neuropsychiatric symptom as a predictor with covariates (age, sex disease duration) and our outcome was patient function. We then performed multivariate analysis with the significant predictors. We observed that apathy explained 20.51% [F(4,68)=5.65, adjusted R2=0.2051; p<0.001], anxiety explained 6.63% [F(4,70)=2.31, adjusted R2=0.0663 p<0.05], and depression was not a significant predictor of patient function. In a multivariate model, apathy and anxiety explained 21.03% [F(5,67)=4.83, adjusted R2=0.2103; p<0.001] of the variance in patient function. These results suggest apathy and anxiety contribute to diminished ability to complete functional activities. | |
dc.eprint.version | Final published version | |
dc.identifier.citation | Crouch, A., & Massimo, L. (2022). APATHY AND ANXIETY ARE RELATED TO POOR FUNCTION IN PERSONS WITH EARLY-ONSET ALZHEIMER’S DISEASE. Innovation in Aging, 6(Supplement_1), 254. https://doi.org/10.1093/geroni/igac059.1007 | |
dc.identifier.uri | https://hdl.handle.net/1805/39960 | |
dc.language.iso | en_US | |
dc.publisher | Oxford University Press | |
dc.relation.isversionof | 10.1093/geroni/igac059.1007 | |
dc.relation.journal | Innovation in Aging | |
dc.rights | Attribution 4.0 International | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.source | Publisher | |
dc.subject | Early-onset Alzheimer’s disease (EOAD) | |
dc.subject | Neuropsychiatric symptoms | |
dc.subject | Caregivers | |
dc.subject | Apathy | |
dc.subject | Anxiety | |
dc.subject | Depression | |
dc.title | Apathy and Anxiety are Related to Poor Function in Persons with Early-Onset Alzheimer’s Disease | |
dc.type | Abstract |