High Unreported Mortality in Children and Youth (<25 Years) Living With HIV Who Were Lost to Care From Antiretroviral Therapy Programs in Southern Africa: Results From a Multicountry Tracing Study

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dc.contributor.authorNyakato, Patience
dc.contributor.authorChrist, Benedikt
dc.contributor.authorAnderegg, Nanina
dc.contributor.authorMuhairwe, Josephine
dc.contributor.authorJefferys, Laura
dc.contributor.authorvan Dijk, Janneke
dc.contributor.authorVinikoor, Michael J.
dc.contributor.authorvan Lettow, Monique
dc.contributor.authorChimbetete, Cleophas
dc.contributor.authorPhiri, Sam J.
dc.contributor.authorEgger, Matthias
dc.contributor.authorBallif, Marie
dc.contributor.authorYiannoutsos, Constantin T.
dc.contributor.authorSchomaker, Michael
dc.contributor.authorKassanjee, Reshma
dc.contributor.authorDavies, Mary-Ann
dc.contributor.authorCornell, Morna
dc.contributor.authorInternational epidemiology Databases to Evaluate AIDS Southern Africa (IeDEA-SA)
dc.contributor.departmentBiostatistics and Health Data Science, School of Medicine
dc.date.accessioned2024-04-23T19:33:12Z
dc.date.available2024-04-23T19:33:12Z
dc.date.issued2022-12-15
dc.description.abstractBackground: Antiretroviral therapy program mortality maybe underestimated if deceased patients are misclassified as lost. Methods: We used two-stage inverse probability weighting to account for probability of being: sampled for tracing and found by the tracer. Results: Among 680 children and youth aged <25 years on antiretroviral therapy who were lost and traced in Southern Africa between October 2017 and November 2019, estimated mortality was high at 9.1% (62/680). After adjusting for measured covariates and within-site clustering, mortality remained lower for young adults aged 20–24 years compared with infants aged <2 years [adjusted hazard ratio: 0.40 (95% confidence interval: 0.31 to 0.51)]. Conclusions: Our study confirms high unreported mortality in children and youth who are lost and the need for tracing to assess vital status among those who are lost to accurately report on program mortality.
dc.eprint.versionFinal published version
dc.identifier.citationNyakato, P., Christ, B., Anderegg, N., Muhairwe, J., Jefferys, L., van Dijk, J., Vinikoor, M. J., van Lettow, M., Chimbetete, C., Phiri, S. J., Egger, M., Ballif, M., Yiannoutsos, C. T., Schomaker, M., Kassanjee, R., Davies, M.-A., Cornell, M., & International epidemiology Databases to Evaluate AIDS Southern Africa (IeDEA-SA). (2022). High Unreported Mortality in Children and Youth (<25 Years) Living With HIV Who Were Lost to Care From Antiretroviral Therapy Programs in Southern Africa: Results From a Multicountry Tracing Study. Journal of Acquired Immune Deficiency Syndromes (1999), 91(5), 429–433. https://doi.org/10.1097/QAI.0000000000003090
dc.identifier.urihttps://hdl.handle.net/1805/40161
dc.language.isoen_US
dc.publisherWolters Kluwer
dc.relation.isversionof10.1097/QAI.0000000000003090
dc.relation.journalJournal of Acquired Immune Deficiency Syndromes
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePublisher
dc.subjectAntiretroviral therapy
dc.subjectmortality
dc.subjectSouthern Africa
dc.subjectunreported rates
dc.subjectmisclassification
dc.subjecttracing
dc.titleHigh Unreported Mortality in Children and Youth (<25 Years) Living With HIV Who Were Lost to Care From Antiretroviral Therapy Programs in Southern Africa: Results From a Multicountry Tracing Study
dc.typeArticle
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