Genome-wide association study identifies 48 common genetic variants associated with handedness

Simple item page
dc.contributor.authorCuellar-Partida, Gabriel
dc.contributor.authorTung, Joyce Y.
dc.contributor.authorEriksson, Nicholas
dc.contributor.authorAlbrecht, Eva
dc.contributor.authorAliev, Fazil
dc.contributor.authorAndreassen, Ole A.
dc.contributor.authorBarroso, Inês
dc.contributor.authorBeckmann, Jacques S.
dc.contributor.authorBoks, Marco P.
dc.contributor.authorBoomsma, Dorret I.
dc.contributor.authorBoyd, Heather A.
dc.contributor.authorBreteler, Monique M. B.
dc.contributor.authorCampbell, Harry
dc.contributor.authorChasman, Daniel I.
dc.contributor.authorCherkas, Lynn F.
dc.contributor.authorDavies, Gail
dc.contributor.authorde Geus, Eco J. C.
dc.contributor.authorDeary, Ian J.
dc.contributor.authorDeloukas, Panos
dc.contributor.authorDick, Danielle M.
dc.contributor.authorDuffy, David L.
dc.contributor.authorEriksson, Johan G.
dc.contributor.authorEsko, Tõnu
dc.contributor.authorFeenstra, Bjarke
dc.contributor.authorGeller, Frank
dc.contributor.authorGieger, Christian
dc.contributor.authorGiegling, Ina
dc.contributor.authorGordon, Scott D.
dc.contributor.authorHan, Jiali
dc.contributor.authorHansen, Thomas F.
dc.contributor.authorHartmann, Annette M.
dc.contributor.authorHayward, Caroline
dc.contributor.authorHeikkilä, Kauko
dc.contributor.authorHicks, Andrew A.
dc.contributor.authorHirschhorn, Joel N.
dc.contributor.authorHottenga, Jouke-Jan
dc.contributor.authorHuffman, Jennifer E.
dc.contributor.authorHwang, Liang-Dar
dc.contributor.authorIkram, M. Arfan
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorKemp, John P.
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorKlopp, Norman
dc.contributor.authorKonte, Bettina
dc.contributor.authorKutalik, Zoltan
dc.contributor.authorLahti, Jari
dc.contributor.authorLi, Xin
dc.contributor.authorLoos, Ruth J. F.
dc.contributor.authorLuciano, Michelle
dc.contributor.authorMagnusson, Sigurdur H.
dc.contributor.authorMangino, Massimo
dc.contributor.authorMarques-Vidal, Pedro
dc.contributor.authorMartin, Nicholas G.
dc.contributor.authorMcArdle, Wendy L.
dc.contributor.authorMcCarthy, Mark I.
dc.contributor.authorMedina-Gomez, Carolina
dc.contributor.authorMelbye, Mads
dc.contributor.authorMelville, Scott A.
dc.contributor.authorMetspalu, Andres
dc.contributor.authorMilani, Lili
dc.contributor.authorMooser, Vincent
dc.contributor.authorNelis, Mari
dc.contributor.authorNyholt, Dale R.
dc.contributor.authorO'Connell, Kevin S.
dc.contributor.authorOphoff, Roel A.
dc.contributor.authorPalmer, Cameron
dc.contributor.authorPalotie, Aarno
dc.contributor.authorPalviainen, Teemu
dc.contributor.authorPare, Guillaume
dc.contributor.authorPaternoster, Lavinia
dc.contributor.authorPeltonen, Leena
dc.contributor.authorPenninx, Brenda W. J. H.
dc.contributor.authorPolasek, Ozren
dc.contributor.authorPramstaller, Peter P.
dc.contributor.authorProkopenko, Inga
dc.contributor.authorRaikkonen, Katri
dc.contributor.authorRipatti, Samuli
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorRudan, Igor
dc.contributor.authorRujescu, Dan
dc.contributor.authorSmit, Johannes H.
dc.contributor.authorSmith, George Davey
dc.contributor.authorSmoller, Jordan W.
dc.contributor.authorSoranzo, Nicole
dc.contributor.authorSpector, Tim D.
dc.contributor.authorSt. Pourcain, Beate
dc.contributor.authorStarr, John M.
dc.contributor.authorStefánsson, Hreinn
dc.contributor.authorSteinberg, Stacy
dc.contributor.authorTeder-Laving, Maris
dc.contributor.authorThorleifsson, Gudmar
dc.contributor.authorStefánsson, Kári
dc.contributor.authorTimpson, Nicholas J.
dc.contributor.authorUitterlinden, André G.
dc.contributor.authorvan Duijn, Cornelia M.
dc.contributor.authorvan Rooij, Frank J. A.
dc.contributor.authorVink, Jaqueline M.
dc.contributor.authorVollenweider, Peter
dc.contributor.authorVuoksimaa, Eero
dc.contributor.authorWaeber, Gérard
dc.contributor.authorWareham, Nicholas J.
dc.contributor.authorWarrington, Nicole
dc.contributor.authorWaterworth, Dawn
dc.contributor.authorWerge, Thomas
dc.contributor.authorWichmann, H-Erich
dc.contributor.authorWiden, Elisabeth
dc.contributor.authorWillemsen, Gonneke
dc.contributor.authorWright, Alan F.
dc.contributor.authorWright, Margaret J.
dc.contributor.authorXu, Mousheng
dc.contributor.authorZhao, Jing Hua
dc.contributor.authorKraft, Peter
dc.contributor.authorHinds, David A.
dc.contributor.authorLindgren, Cecilia M.
dc.contributor.authorMägi, Reedik
dc.contributor.authorNeale, Benjamin M.
dc.contributor.authorEvans, David M.
dc.contributor.authorMedland, Sarah E.
dc.contributor.departmentEpidemiology, School of Public Health
dc.date.accessioned2024-03-07T12:12:56Z
dc.date.available2024-03-07T12:12:56Z
dc.date.issued2021
dc.description.abstractHandedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10-8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationCuellar-Partida G, Tung JY, Eriksson N, et al. Genome-wide association study identifies 48 common genetic variants associated with handedness. Nat Hum Behav. 2021;5(1):59-70. doi:10.1038/s41562-020-00956-y
dc.identifier.urihttps://hdl.handle.net/1805/39075
dc.language.isoen_US
dc.publisherSpringer Nature
dc.relation.isversionof10.1038/s41562-020-00956-y
dc.relation.journalNature Human Behaviour
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectFunctional laterality
dc.subjectGenetic loci
dc.subjectLinkage disequilibrium
dc.subjectSex factors
dc.titleGenome-wide association study identifies 48 common genetic variants associated with handedness
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
EMS109952.pdf
Size:
969.12 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.99 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Open Access Policy Articles
Department of Epidemiology Works