Micropetrosis in hemodialysis patients

dc.contributor.authorYajima, Aiji
dc.contributor.authorTsuchiya, Ken
dc.contributor.authorBurr, David B.
dc.contributor.authorMurata, Taro
dc.contributor.authorNakamura, Masaki
dc.contributor.authorInaba, Masaaki
dc.contributor.authorTominaga, Yoshihiro
dc.contributor.authorTanizawa, Tatsuhiko
dc.contributor.authorNakayama, Takashi
dc.contributor.authorIto, Akemi
dc.contributor.authorNitta, Kosaku
dc.contributor.departmentAnatomy, Cell Biology and Physiology, School of Medicineen_US
dc.date.accessioned2023-04-13T13:01:34Z
dc.date.available2023-04-13T13:01:34Z
dc.date.issued2021-11-27
dc.description.abstractMicropetrosis develops as a result of stagnation of calcium, phosphorus and bone fluid, which appears as highly mineralized bone area in the osteocytic perilacunar/canalicular system regardless of bone turnover of the patients. And microcracks are predisposed to increase in these areas, which leads to increased bone fragility. However, micropetrosis of hemodialysis (HD) patients has not been discussed at all. Micropetrosis area per bone area (Mp.Ar/B·Ar) and osteocyte number per micropetrosis area (Ot.N/Mp.Ar) were measured in nine HD patients with renal hyperparathyroidism (Group I), twelve patients with hypoparathyroidism within 1 year after the treatment of renal hyperparathyroidism (Group II) and seven patients suffering from hypoparathyroidism for over two years (Group III). And bone mineral density (BMD) and tissue mineral density (TMD) were calculated using μCT to evaluate bone mineral content of iliac bone of the patients. These parameters were compared among the three groups. Only Mp.Ar/B·Ar was statistically greater in Group II and III compared to Group I in the parameters of bone mineral content and micropetrosis. However, the other parameters were not statistically different among the three groups. In long-term HD patients, BMD and TMD may be modified by the causes of renal insufficiency and the treatment of renal bone disease. We concluded that Mp.Ar/B·Ar was greater in patients with long-term hypoparathyroidism than both those with short-term hypoparathyroidism and with renal hyperparathyroidism. Special attention should be paid to avoid long-term hypoparathyroidism of the patients from the view point of increased fracture risk caused by increased micropetrosis area.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationYajima A, Tsuchiya K, Burr DB, et al. Micropetrosis in hemodialysis patients. Bone Rep. 2021;15:101150. Published 2021 Nov 27. doi:10.1016/j.bonr.2021.101150en_US
dc.identifier.urihttps://hdl.handle.net/1805/32383
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.bonr.2021.101150en_US
dc.relation.journalBone Reportsen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourcePMCen_US
dc.subjectMicropetrosisen_US
dc.subjectBone histomorphometryen_US
dc.subjectμCTen_US
dc.subjectHemodialysis patientsen_US
dc.subjectFracture risken_US
dc.titleMicropetrosis in hemodialysis patientsen_US
dc.typeArticleen_US
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