Microstructural Constitutive Model of Active Coronary Media

dc.contributor.authorChen, Huan
dc.contributor.authorLuo, Tong
dc.contributor.authorZhao, Xuefeng
dc.contributor.authorLu, Xiao
dc.contributor.authorHuo, Yunlong
dc.contributor.authorKassab, Ghassan S.
dc.contributor.departmentSurgery, School of Medicine
dc.date.accessioned2025-05-05T15:59:49Z
dc.date.available2025-05-05T15:59:49Z
dc.date.issued2013
dc.description.abstractAlthough vascular smooth muscle cells (VSMCs) are pivotal in physiology and pathology, there is a lack of detailed morphological data on these cells. The objective of this study was to determine dimensions (width and length) and orientation of swine coronary VSMCs and to develop a microstructural constitutive model of active media. The dimensions, spatial aspect ratio and orientation angle of VSMCs measured at zero-stress state were found to follow continuous normal (or bimodal normal) distributions. The VSMCs aligned off circumferential direction of blood vessels with symmetrical polar angles 18.7° ± 10.9°, and the local VSMC deformation was affine with tissue-level deformation. A microstructure-based active constitutive model was developed to predict the biaxial vasoactivity of coronary media, based on experimental measurements of geometrical and deformation features of VSMCs. The results revealed that the axial active response of blood vessels is associated with multi-axial contraction as well as oblique VSMC arrangement. The present morphological database is essential for developing accurate structural models and is seminal for understanding the biomechanics of muscular vessels.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationChen H, Luo T, Zhao X, Lu X, Huo Y, Kassab GS. Microstructural constitutive model of active coronary media. Biomaterials. 2013;34(31):7575-7583. doi:10.1016/j.biomaterials.2013.06.035
dc.identifier.urihttps://hdl.handle.net/1805/47730
dc.language.isoen_US
dc.publisherElsevier
dc.relation.isversionof10.1016/j.biomaterials.2013.06.035
dc.relation.journalBiomaterials
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectBiaxial vasoactivity
dc.subjectCoronary artery
dc.subjectDeformation
dc.subjectMorphology
dc.subjectVascular smooth muscle cell
dc.titleMicrostructural Constitutive Model of Active Coronary Media
dc.typeArticle
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