The current state of biomarker research for Friedreich's ataxia: a report from the 2018 FARA biomarker meeting

dc.contributor.authorBlair, Ian A.
dc.contributor.authorFarmer, Jennifer
dc.contributor.authorHersch, Steven
dc.contributor.authorLarkindale, Jane
dc.contributor.authorLynch, David R.
dc.contributor.authorNapierala, Jill
dc.contributor.authorNapierala, Marek
dc.contributor.authorPayne, R. Mark
dc.contributor.authorSubramony, Sub H.
dc.contributor.departmentDepartment of Medicine, IU School of Medicineen_US
dc.date.accessioned2019-09-09T17:34:40Z
dc.date.available2019-09-09T17:34:40Z
dc.date.issued2019-06-28
dc.description.abstractThe 2018 FARA Biomarker Meeting highlighted the current state of development of biomarkers for Friedreich's ataxia. A mass spectroscopy assay to sensitively measure mature frataxin (reduction of which is the root cause of disease) is being developed. Biomarkers to monitor neurological disease progression include imaging, electrophysiological measures and measures of nerve function, which may be measured either in serum and/or through imaging-based technologies. Potential pharmacodynamic biomarkers include metabolic and protein biomarkers and markers of nerve damage. Cardiac imaging and serum biomarkers may reflect cardiac disease progression. Considerable progress has been made in the development of biomarkers for various contexts of use, but further work is needed in terms of larger longitudinal multisite studies, and identification of novel biomarkers for additional use cases.en_US
dc.identifier.citationBlair, I. A., Farmer, J., Hersch, S., Larkindale, J., Lynch, D. R., Napierala, J., … Subramony, S. H. (2019). The current state of biomarker research for Friedreich's ataxia: a report from the 2018 FARA biomarker meeting. Future science OA, 5(6), FSO398. doi:10.2144/fsoa-2019-0026en_US
dc.identifier.urihttps://hdl.handle.net/1805/20879
dc.language.isoen_USen_US
dc.publisherFuture Science Groupen_US
dc.relation.isversionof10.2144/fsoa-2019-0026en_US
dc.relation.journalFuture Science OAen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/us*
dc.sourcePMCen_US
dc.subjectFriedreich’s ataxiaen_US
dc.subjectBiomarkersen_US
dc.subjectDrug developmenten_US
dc.titleThe current state of biomarker research for Friedreich's ataxia: a report from the 2018 FARA biomarker meetingen_US
dc.typeArticleen_US
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