A facile hydroxyindole carboxylic acid based focused library approach for potent and selective inhibitors of Mycobacterium protein tyrosine phosphatase B

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dc.contributor.authorZeng, Li-Fan
dc.contributor.authorXu, Jie
dc.contributor.authorHe, Yantao
dc.contributor.authorHe, Rongjun
dc.contributor.authorWu, Li
dc.contributor.authorGunawan, Andrea M.
dc.contributor.authorZhang, Zhong-Yin
dc.contributor.departmentBiochemistry and Molecular Biology, School of Medicine
dc.date.accessioned2025-05-12T13:09:05Z
dc.date.available2025-05-12T13:09:05Z
dc.date.issued2013
dc.description.abstractFocused on Mtb: A facile hydroxyindole carboxylic acid based focused amide library was designed to target both the PTP active site and a unique nearby pocket for enhanced affinity and selectivity. HTS of the library led to the identification of a highly potent and selective inhibitor, 11 a, of mPTPB, an essential virulence factor for Mycobacterium tuberculosis. Compound 11 a shows high cellular activity and is capable of reversing the altered immune responses induced by mPTPB in macrophages.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationZeng LF, Xu J, He Y, et al. A facile hydroxyindole carboxylic acid based focused library approach for potent and selective inhibitors of Mycobacterium protein tyrosine phosphatase B. ChemMedChem. 2013;8(6):904-908. doi:10.1002/cmdc.201300115
dc.identifier.urihttps://hdl.handle.net/1805/47967
dc.language.isoen_US
dc.publisherWiley
dc.relation.isversionof10.1002/cmdc.201300115
dc.relation.journalChemMedChem
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectFocused amide library
dc.subjectHydroxyIndole carboxylic acid
dc.subjectPTP
dc.subjectmPTPB inhibitor
dc.subjectTuberculosis
dc.titleA facile hydroxyindole carboxylic acid based focused library approach for potent and selective inhibitors of Mycobacterium protein tyrosine phosphatase B
dc.typeArticle
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