Klotho: An Emerging Factor With Ergogenic Potential

dc.contributor.authorArroyo, Eliott
dc.contributor.authorTroutman, Ashley D.
dc.contributor.authorMoorthi, Ranjani N.
dc.contributor.authorAvin, Keith G.
dc.contributor.authorCoggan, Andrew R.
dc.contributor.authorLim, Kenneth
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2022-06-28T14:35:58Z
dc.date.available2022-06-28T14:35:58Z
dc.date.issued2022-01
dc.description.abstractSarcopenia and impaired cardiorespiratory fitness are commonly observed in older individuals and patients with chronic kidney disease (CKD). Declines in skeletal muscle function and aerobic capacity can progress into impaired physical function and inability to perform activities of daily living. Physical function is highly associated with important clinical outcomes such as hospitalization, functional independence, quality of life, and mortality. While lifestyle modifications such as exercise and dietary interventions have been shown to prevent and reverse declines in physical function, the utility of these treatment strategies is limited by poor widespread adoption and adherence due to a wide variety of both perceived and actual barriers to exercise. Therefore, identifying novel treatment targets to manage physical function decline is critically important. Klotho, a remarkable protein with powerful anti-aging properties has recently been investigated for its role in musculoskeletal health and physical function. Klotho is involved in several key processes that regulate skeletal muscle function, such as muscle regeneration, mitochondrial biogenesis, endothelial function, oxidative stress, and inflammation. This is particularly important for older adults and patients with CKD, which are known states of Klotho deficiency. Emerging data support the existence of Klotho-related benefits to exercise and for potential Klotho-based therapeutic interventions for the treatment of sarcopenia and its progression to physical disability. However, significant gaps in our understanding of Klotho must first be overcome before we can consider its potential ergogenic benefits. These advances will be critical to establish the optimal approach to future Klotho-based interventional trials and to determine if Klotho can regulate physical dysfunction.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationArroyo, E., Troutman, A. D., Moorthi, R. N., Avin, K. G., Coggan, A. R., & Lim, K. (2022). Klotho: An Emerging Factor With Ergogenic Potential. Frontiers in Rehabilitation Sciences, 2, 807123. https://doi.org/10.3389/fresc.2021.807123en_US
dc.identifier.issn2673-6861en_US
dc.identifier.urihttps://hdl.handle.net/1805/29433
dc.language.isoen_USen_US
dc.publisherFrontiersen_US
dc.relation.isversionof10.3389/fresc.2021.807123en_US
dc.relation.journalFrontiers in Rehabilitation Sciencesen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0*
dc.sourcePublisheren_US
dc.subjectSarcopeniaen_US
dc.subjectskeletal muscle functionen_US
dc.subjectKlothoen_US
dc.titleKlotho: An Emerging Factor With Ergogenic Potentialen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Arroyo2022Klotho-CCBY.pdf
Size:
757.86 KB
Format:
Adobe Portable Document Format
Description:
Article
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.99 KB
Format:
Item-specific license agreed upon to submission
Description: