The Functional Roles of Immune Cells in Primary Liver Cancer
dc.contributor.author | Pham, Linh | |
dc.contributor.author | Kyritsi, Konstantina | |
dc.contributor.author | Zhou, Tianhao | |
dc.contributor.author | Ceci, Ludovica | |
dc.contributor.author | Baiocchi, Leonardo | |
dc.contributor.author | Kennedy, Lindsey | |
dc.contributor.author | Chakraborty, Sanjukta | |
dc.contributor.author | Glaser, Shannon | |
dc.contributor.author | Francis, Heather | |
dc.contributor.author | Alpini, Gianfranco | |
dc.contributor.author | Sato, Keisaku | |
dc.contributor.department | Medicine, School of Medicine | |
dc.date.accessioned | 2024-01-18T13:49:44Z | |
dc.date.available | 2024-01-18T13:49:44Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Primary liver cancer includes hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). Incidence of liver cancer has been increasing in recent years, and the 5-year survival is <20%. HCC and CCA are often accompanied with a dense stroma coupled with infiltrated immune cells, which is referred to as the tumor microenvironment. Populations of specific immune cells, such as high density of CD163+ macrophages and low density of CD8+ T cells, are associated with prognosis and survival rates in both HCC and CCA. Immune cells in the tumor microenvironment can be a therapeutic target for liver cancer treatments. Previous studies have introduced immunotherapy using immune checkpoint inhibitors, pulsed dendritic cells, or transduced T cells, to enhance cytotoxicity of immune cells and inhibit tumor growth. This review summarizes current understanding of the roles of immune cells in primary liver cancer covering HCC and CCA. | |
dc.eprint.version | Final published version | |
dc.identifier.citation | Pham L, Kyritsi K, Zhou T, et al. The Functional Roles of Immune Cells in Primary Liver Cancer. Am J Pathol. 2022;192(6):826-836. doi:10.1016/j.ajpath.2022.02.004 | |
dc.identifier.uri | https://hdl.handle.net/1805/38071 | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | |
dc.relation.isversionof | 10.1016/j.ajpath.2022.02.004 | |
dc.relation.journal | The American Journal of Pathology | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | Bile duct neoplasms | |
dc.subject | Cholangiocarcinoma | |
dc.subject | Liver neoplasms | |
dc.subject | Tumor microenvironment | |
dc.title | The Functional Roles of Immune Cells in Primary Liver Cancer | |
dc.type | Article | |
ul.alternative.fulltext | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194651/ |