The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality

Li, Chaofan; Zhu, Bibo; Son, Young Min; Wang, Zheng; Jiang, Li; Xiang, Min; Ye, Zhenqing; Beckermann, Kathryn E.; Wu, Yue; Jenkins, James W.; Siska, Peter J.; Vincent, Benjamin G.; Prakash, Y. S.; Peikert, Tobias; Edelson, Brian T.; Taneja, Reshma; Kaplan, Mark H.; Rathmell, Jeffrey C.; Dong, Haidong; Hitosugi, Taro; Sun, Jie

The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality

Files

nihms-1538544.pdf (1.37 MB)

Date

2019-09-17

Language

American English

Department

Microbiology and Immunology, School of Medicine

Found At

Elsevier

Keywords

Basic Helix-Loop-Helix Transcription Factors, CD8-Positive T-Lymphocytes, Gene Expression Regulation, Homeodomain Proteins, tissue resident memory T cell, tumor-infiltrating lymphocytes, Bhlhe40, mitochondria, epigenetic, Tubastatin A, acetate, PD-L1, metabolism

Cite As

Li, C., Zhu, B., Son, Y. M., Wang, Z., Jiang, L., Xiang, M., Ye, Z., Beckermann, K. E., Wu, Y., Jenkins, J. W., Siska, P. J., Vincent, B. G., Prakash, Y. S., Peikert, T., Edelson, B. T., Taneja, R., Kaplan, M. H., Rathmell, J. C., Dong, H., … Sun, J. (2019). The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality. Immunity, 51(3), 491-507.e7. https://doi.org/10.1016/j.immuni.2019.08.013

ISSN

1074-7613

Journal

Immunity

Rights

Source

PMC

Type

Article

Permanent Link

https://hdl.handle.net/1805/25891

DOI

https://doi.org/10.1016/j.immuni.2019.08.013

Version

Author's manuscript

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