Multimodal data integration via mediation analysis with high-dimensional exposures and mediators
dc.contributor.author | Zhao, Yi | |
dc.contributor.author | Li, Lexin | |
dc.contributor.author | Alzheimer's Disease Neuroimaging Initiative | |
dc.contributor.department | Biostatistics and Health Data Science, School of Medicine | |
dc.date.accessioned | 2023-06-19T10:55:33Z | |
dc.date.available | 2023-06-19T10:55:33Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Motivated by an imaging proteomics study for Alzheimer's disease (AD), in this article, we propose a mediation analysis approach with high-dimensional exposures and high-dimensional mediators to integrate data collected from multiple platforms. The proposed method combines principal component analysis with penalized least squares estimation for a set of linear structural equation models. The former reduces the dimensionality and produces uncorrelated linear combinations of the exposure variables, whereas the latter achieves simultaneous path selection and effect estimation while allowing the mediators to be correlated. Applying the method to the AD data identifies numerous interesting protein peptides, brain regions, and protein-structure-memory paths, which are in accordance with and also supplement existing findings of AD research. Additional simulations further demonstrate the effective empirical performance of the method. | en_US |
dc.eprint.version | Final published version | en_US |
dc.identifier.citation | Zhao Y, Li L; Alzheimer's Disease Neuroimaging Initiative. Multimodal data integration via mediation analysis with high-dimensional exposures and mediators. Hum Brain Mapp. 2022;43(8):2519-2533. doi:10.1002/hbm.25800 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/33845 | |
dc.language.iso | en_US | en_US |
dc.publisher | Wiley | en_US |
dc.relation.isversionof | 10.1002/hbm.25800 | en_US |
dc.relation.journal | Human Brain Mapping | en_US |
dc.rights | Attribution-NonCommercial 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.source | PMC | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.subject | Mediation analysis | en_US |
dc.subject | Multimodal data integration | en_US |
dc.subject | Neuroimaging | en_US |
dc.subject | Principal component analysis | en_US |
dc.title | Multimodal data integration via mediation analysis with high-dimensional exposures and mediators | en_US |
dc.type | Article | en_US |