Molecular Mechanisms of Nonalcoholic Fatty Liver Disease: Potential Role for 12-Lipoxygenase

dc.contributor.authorSamala, Niharika
dc.contributor.authorTersey, Sarah A.
dc.contributor.authorChalasani, Naga
dc.contributor.authorAnderson, Ryan M.
dc.contributor.authorMirmira, Raghavendra G.
dc.contributor.departmentDepartment of Biochemistry and Molecular Biology, School of Medicineen_US
dc.date.accessioned2017-09-20T14:29:28Z
dc.date.available2017-09-20T14:29:28Z
dc.date.issued2017
dc.description.abstractNonalcoholic fatty liver disease (NAFLD) is a spectrum of pathologies associated with fat accumulation in the liver. NAFLD is the most common cause of liver disease in the United States, affecting up to a third of the general population. It is commonly associated with features of metabolic syndrome, particularly insulin resistance. NAFLD shares the basic pathogenic mechanisms with obesity and insulin resistance, such as mitochondrial, oxidative and endoplasmic reticulum stress. Lipoxygenases catalyze the conversion of poly-unsaturated fatty acids in the plasma membrane—mainly arachidonic acid and linoleic acid—to produce oxidized pro-inflammatory lipid intermediates. 12-Lipoxygenase (12-LOX) has been studied extensively in setting of inflammation and insulin resistance. As insulin resistance is closely associated with development of NAFLD, the role of 12-LOX in pathogenesis of NAFLD has received increasing attention in recent years. In this review we discuss the role of 12-LOX in NAFLD pathogenesis and its potential role in emerging new therapeutics.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationSamala, N., Tersey, S. A., Chalasani, N., Anderson, R. M., & Mirmira, R. G. (2017). Molecular Mechanisms of Nonalcoholic Fatty Liver Disease: Potential Role for 12-Lipoxygenase. Journal of Diabetes and Its Complications. https://doi.org/10.1016/j.jdiacomp.2017.07.014en_US
dc.identifier.urihttps://hdl.handle.net/1805/14125
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.jdiacomp.2017.07.014en_US
dc.relation.journalJournal of Diabetes and Its Complicationsen_US
dc.rightsPublisher Policyen_US
dc.sourceAuthoren_US
dc.subjectnon-alcoholic fatty liver diseaseen_US
dc.subjectlipoxygenaseen_US
dc.subjectoxidative stressen_US
dc.titleMolecular Mechanisms of Nonalcoholic Fatty Liver Disease: Potential Role for 12-Lipoxygenaseen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Samala_2017_molecular.pdf
Size:
419.02 KB
Format:
Adobe Portable Document Format
Description:
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.88 KB
Format:
Item-specific license agreed upon to submission
Description: