Health Impairments in Children and Adolescents After Hospitalization for Acute COVID-19 or MIS-C
dc.contributor.author | Maddux, Aline B. | |
dc.contributor.author | Berbert, Laura | |
dc.contributor.author | Young, Cameron C. | |
dc.contributor.author | Feldstein, Leora R. | |
dc.contributor.author | Zambrano, Laura D. | |
dc.contributor.author | Kucukak, Suden | |
dc.contributor.author | Newhams, Margaret M. | |
dc.contributor.author | Miller, Kristen | |
dc.contributor.author | FitzGerald, Madyson M. | |
dc.contributor.author | He, Jie | |
dc.contributor.author | Halasa, Natasha B. | |
dc.contributor.author | Cvijanovich, Natalie Z. | |
dc.contributor.author | Loftis, Laura L. | |
dc.contributor.author | Walker, Tracie C. | |
dc.contributor.author | Schwartz, Stephanie P. | |
dc.contributor.author | Gertz, Shira J. | |
dc.contributor.author | Tarquinio, Keiko M. | |
dc.contributor.author | Fitzgerald, Julie C. | |
dc.contributor.author | Kong, Michele | |
dc.contributor.author | Schuster, Jennifer E. | |
dc.contributor.author | Mack, Elizabeth H. | |
dc.contributor.author | Hobbs, Charlotte V. | |
dc.contributor.author | Rowan, Courtney M. | |
dc.contributor.author | Staat, Mary A. | |
dc.contributor.author | Zinter, Matt S. | |
dc.contributor.author | Irby, Katherine | |
dc.contributor.author | Crandall, Hillary | |
dc.contributor.author | Flori, Heidi | |
dc.contributor.author | Cullimore, Melissa L. | |
dc.contributor.author | Nofziger, Ryan A. | |
dc.contributor.author | Shein, Steven L. | |
dc.contributor.author | Glas Gaspers, Mary | |
dc.contributor.author | Hume, Janet R. | |
dc.contributor.author | Levy, Emily R. | |
dc.contributor.author | Chen, Sabrina R. | |
dc.contributor.author | Patel, Manish M. | |
dc.contributor.author | Tenforde, Mark W. | |
dc.contributor.author | Weller, Edie | |
dc.contributor.author | Campbell, Angela P. | |
dc.contributor.author | Randolph, Adrienne G. | |
dc.contributor.author | Overcoming COVID-19 Investigators | |
dc.contributor.department | Pediatrics, School of Medicine | |
dc.date.accessioned | 2024-03-14T14:56:03Z | |
dc.date.available | 2024-03-14T14:56:03Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Objectives: To evaluate risk factors for postdischarge sequelae in children and adolescents hospitalized for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C). Methods: Multicenter prospective cohort study conducted in 25 United States pediatric hospitals. Patients <21-years-old, hospitalized May 2020 to May 2021 for acute COVID-19 or MIS-C with follow-up 2 to 4 months after admission. We assessed readmissions, persistent symptoms or activity impairment, and new morbidities. Multivariable regression was used to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI). Results: Of 358 eligible patients, 2 to 4 month survey data were available for 119 of 155 (76.8%) with acute COVID-19 and 160 of 203 (78.8%) with MIS-C. Thirteen (11%) patients with acute COVID-19 and 12 (8%) with MIS-C had a readmission. Thirty-two (26.9%) patients with acute COVID-19 had persistent symptoms (22.7%) or activity impairment (14.3%) and 48 (30.0%) with MIS-C had persistent symptoms (20.0%) or activity impairment (21.3%). For patients with acute COVID-19, persistent symptoms (aRR, 1.29 [95% CI, 1.04-1.59]) and activity impairment (aRR, 1.37 [95% CI, 1.06-1.78]) were associated with more organ systems involved. Patients with MIS-C and pre-existing respiratory conditions more frequently had persistent symptoms (aRR, 3.09 [95% CI, 1.55-6.14]) and those with obesity more frequently had activity impairment (aRR, 2.52 [95% CI, 1.35-4.69]). New morbidities were infrequent (9% COVID-19, 1% MIS-C). Conclusions: Over 1 in 4 children hospitalized with acute COVID-19 or MIS-C experienced persistent symptoms or activity impairment for at least 2 months. Patients with MIS-C and respiratory conditions or obesity are at higher risk of prolonged recovery. | |
dc.eprint.version | Author's manuscript | |
dc.identifier.citation | Maddux AB, Berbert L, Young CC, et al. Health Impairments in Children and Adolescents After Hospitalization for Acute COVID-19 or MIS-C. Pediatrics. 2022;150(3):e2022057798. doi:10.1542/peds.2022-057798 | |
dc.identifier.uri | https://hdl.handle.net/1805/39248 | |
dc.language.iso | en_US | |
dc.publisher | American Academy of Pediatrics | |
dc.relation.isversionof | 10.1542/peds.2022-057798 | |
dc.relation.journal | Pediatrics | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | Post-acute COVID-19 syndrome | |
dc.subject | COVID-19 post-intensive care syndrome | |
dc.subject | Critical care outcomes | |
dc.subject | SARS-CoV-2 | |
dc.subject | Multisystem inflammatory syndrome in children | |
dc.subject | MIS-C | |
dc.subject | COVID-19 | |
dc.subject | Pediatrics | |
dc.title | Health Impairments in Children and Adolescents After Hospitalization for Acute COVID-19 or MIS-C | |
dc.type | Article |