Associations of Metabolic syndrome and C-reactive protein with Mortality from total cancer, obesity-linked cancers and Breast Cancer among Women in NHANES III

dc.contributor.authorGathirua-Mwangi, Wambui G.
dc.contributor.authorSong, Yiqing
dc.contributor.authorMonahan, Patrick
dc.contributor.authorChampion, Victoria L.
dc.contributor.authorZollinger, Terrell
dc.contributor.departmentBiostatistics, School of Public Healthen_US
dc.date.accessioned2019-10-04T13:22:59Z
dc.date.available2019-10-04T13:22:59Z
dc.date.issued2018-08
dc.description.abstractAlthough metabolic syndrome (MetS) is a prognostic factor for cancer occurrence, the association of MetS and cancer mortality remains unclear. The purpose of this study was to evaluate whether MetS, components of MetS and C-reactive protein (CRP) are associated with cancer mortality in women. A total of 400 cancer deaths, with 140 deaths from obesity-linked-cancers (OLCas), [breast (BCa), colorectal, pancreatic and endometrial], linked through the National Death Index, were identified from 10,104 eligible subjects aged ≥18 years. Cox proportional hazards regression was used to estimate multivariable-adjusted hazard ratios (HR) for cancer mortality. MetS was associated with increased deaths for total cancer [HR = 1.33, 95% confidence interval (CI) 1.04-1.70] and BCa [HR = 2.1, 95% CI, 1.09-4.11]. The risk of total cancer [HR = 1.7, 95% CI, 1.12-2.68], OLCas [HR = 2.1, 95% CI, 1.00-4.37] and BCa [HR = 3.8, 95% CI, 1.34-10.91] mortality was highest for women with all MetS components abnormal, compared to those without MetS. Linear associations of blood-pressure [HR = 2.5, 1.02-6.12, Quartile (Q) 4 vs Q1, p trend = 0.004] and blood-glucose [HR = 2.2, 1.04-4.60, Q4 vs. Q1, p trend = 0.04] with total-OLCas mortality were observed. A threefold increased risk of BCa mortality was observed for women with enlarged waist circumference, ≥100.9 cm, [HR = 3.5, 1.14-10.51, p trend = 0.008] and in those with increased blood glucose, ≥101 mg/dL, [HR = 3.2, 1.11-9.20, p trend = 0.03] compared to those in Q1. None of the components of MetS were associated with total-cancer mortality. CRP was not associated with cancer mortality. In conclusion, MetS is associated with total-cancer and breast-cancer mortality, with waist circumference, blood pressure and blood glucose as independent predictors of OLCas and BCa mortality.en_US
dc.identifier.citationGathirua-Mwangi, W. G., Song, Y., Monahan, P. O., Champion, V. L., & Zollinger, T. W. (2018). Associations of metabolic syndrome and C-reactive protein with mortality from total cancer, obesity-linked cancers and breast cancer among women in NHANES III. International journal of cancer, 143(3), 535–542. doi:10.1002/ijc.31344en_US
dc.identifier.urihttps://hdl.handle.net/1805/21029
dc.language.isoen_USen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/ijc.31344en_US
dc.relation.journalInternational Journal of Canceren_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.sourcePMCen_US
dc.subjectMetabolic syndromeen_US
dc.subjectC - reactive proteinen_US
dc.subjectCancer mortalityen_US
dc.subjectObesity-linked cancersen_US
dc.subjectBreast canceren_US
dc.subjectWomenen_US
dc.subjectCohort studyen_US
dc.subjectEpidemiologyen_US
dc.titleAssociations of Metabolic syndrome and C-reactive protein with Mortality from total cancer, obesity-linked cancers and Breast Cancer among Women in NHANES IIIen_US
dc.typeArticleen_US
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