Associations of Metabolic syndrome and C-reactive protein with Mortality from total cancer, obesity-linked cancers and Breast Cancer among Women in NHANES III
dc.contributor.author | Gathirua-Mwangi, Wambui G. | |
dc.contributor.author | Song, Yiqing | |
dc.contributor.author | Monahan, Patrick | |
dc.contributor.author | Champion, Victoria L. | |
dc.contributor.author | Zollinger, Terrell | |
dc.contributor.department | Biostatistics, School of Public Health | en_US |
dc.date.accessioned | 2019-10-04T13:22:59Z | |
dc.date.available | 2019-10-04T13:22:59Z | |
dc.date.issued | 2018-08 | |
dc.description.abstract | Although metabolic syndrome (MetS) is a prognostic factor for cancer occurrence, the association of MetS and cancer mortality remains unclear. The purpose of this study was to evaluate whether MetS, components of MetS and C-reactive protein (CRP) are associated with cancer mortality in women. A total of 400 cancer deaths, with 140 deaths from obesity-linked-cancers (OLCas), [breast (BCa), colorectal, pancreatic and endometrial], linked through the National Death Index, were identified from 10,104 eligible subjects aged ≥18 years. Cox proportional hazards regression was used to estimate multivariable-adjusted hazard ratios (HR) for cancer mortality. MetS was associated with increased deaths for total cancer [HR = 1.33, 95% confidence interval (CI) 1.04-1.70] and BCa [HR = 2.1, 95% CI, 1.09-4.11]. The risk of total cancer [HR = 1.7, 95% CI, 1.12-2.68], OLCas [HR = 2.1, 95% CI, 1.00-4.37] and BCa [HR = 3.8, 95% CI, 1.34-10.91] mortality was highest for women with all MetS components abnormal, compared to those without MetS. Linear associations of blood-pressure [HR = 2.5, 1.02-6.12, Quartile (Q) 4 vs Q1, p trend = 0.004] and blood-glucose [HR = 2.2, 1.04-4.60, Q4 vs. Q1, p trend = 0.04] with total-OLCas mortality were observed. A threefold increased risk of BCa mortality was observed for women with enlarged waist circumference, ≥100.9 cm, [HR = 3.5, 1.14-10.51, p trend = 0.008] and in those with increased blood glucose, ≥101 mg/dL, [HR = 3.2, 1.11-9.20, p trend = 0.03] compared to those in Q1. None of the components of MetS were associated with total-cancer mortality. CRP was not associated with cancer mortality. In conclusion, MetS is associated with total-cancer and breast-cancer mortality, with waist circumference, blood pressure and blood glucose as independent predictors of OLCas and BCa mortality. | en_US |
dc.identifier.citation | Gathirua-Mwangi, W. G., Song, Y., Monahan, P. O., Champion, V. L., & Zollinger, T. W. (2018). Associations of metabolic syndrome and C-reactive protein with mortality from total cancer, obesity-linked cancers and breast cancer among women in NHANES III. International journal of cancer, 143(3), 535–542. doi:10.1002/ijc.31344 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/21029 | |
dc.language.iso | en_US | en_US |
dc.publisher | Wiley | en_US |
dc.relation.isversionof | 10.1002/ijc.31344 | en_US |
dc.relation.journal | International Journal of Cancer | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.source | PMC | en_US |
dc.subject | Metabolic syndrome | en_US |
dc.subject | C - reactive protein | en_US |
dc.subject | Cancer mortality | en_US |
dc.subject | Obesity-linked cancers | en_US |
dc.subject | Breast cancer | en_US |
dc.subject | Women | en_US |
dc.subject | Cohort study | en_US |
dc.subject | Epidemiology | en_US |
dc.title | Associations of Metabolic syndrome and C-reactive protein with Mortality from total cancer, obesity-linked cancers and Breast Cancer among Women in NHANES III | en_US |
dc.type | Article | en_US |