Sex, racial, and APOE-ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer’s disease

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dc.contributor.authorPeterson, Amalia
dc.contributor.authorSathe, Aditi
dc.contributor.authorZaras, Dimitrios
dc.contributor.authorYang, Yisu
dc.contributor.authorDurant, Alaina
dc.contributor.authorDeters, Kacie D.
dc.contributor.authorShashikumar, Niranjana
dc.contributor.authorPechman, Kimberly R.
dc.contributor.authorKim, Michael E.
dc.contributor.authorGao, Chenyu
dc.contributor.authorKhairi, Nazirah Mohd
dc.contributor.authorLi, Zhiyuan
dc.contributor.authorYao, Tianyuan
dc.contributor.authorHuo, Yuankai
dc.contributor.authorDumitrescu, Logan
dc.contributor.authorGifford, Katherine A.
dc.contributor.authorWilson, Jo Ellen
dc.contributor.authorCambronero, Francis
dc.contributor.authorRisacher, Shannon L.
dc.contributor.authorBeason-Held, Lori L.
dc.contributor.authorAn, Yang
dc.contributor.authorArfanakis, Konstantinos
dc.contributor.authorErus, Guray
dc.contributor.authorDavatzikos, Christos
dc.contributor.authorTosun, Duygu
dc.contributor.authorToga, Arthur W.
dc.contributor.authorThompson, Paul M.
dc.contributor.authorMormino, Elizabeth C.
dc.contributor.authorZhang, Panpan
dc.contributor.authorSchilling, Kurt
dc.contributor.authorAlzheimer’s Disease Neuroimaging Initiative (ADNI)
dc.contributor.authorBIOCARD Study Team; Alzheimer’s Disease Sequencing Project (ADSP)
dc.contributor.authorAlbert, Marilyn
dc.contributor.authorKukull, Walter
dc.contributor.authorBiber, Sarah A.
dc.contributor.authorLandman, Bennett A.
dc.contributor.authorJohnson, Sterling C.
dc.contributor.authorSchneider, Julie
dc.contributor.authorBarnes, Lisa L.
dc.contributor.authorBennett, David A.
dc.contributor.authorJefferson, Angela L.
dc.contributor.authorResnick, Susan M.
dc.contributor.authorSaykin, Andrew J.
dc.contributor.authorHohman, Timothy J.
dc.contributor.authorArcher, Derek B.
dc.contributor.departmentRadiology and Imaging Sciences, School of Medicine
dc.date.accessioned2024-08-30T10:04:25Z
dc.date.available2024-08-30T10:04:25Z
dc.date.issued2024-06-12
dc.description.abstractIntroduction: The effects of sex, race, and Apolipoprotein E (APOE) - Alzheimer's disease (AD) risk factors - on white matter integrity are not well characterized. Methods: Diffusion MRI data from nine well-established longitudinal cohorts of aging were free-water (FW)-corrected and harmonized. This dataset included 4,702 participants (age=73.06 ± 9.75) with 9,671 imaging sessions over time. FW and FW-corrected fractional anisotropy (FAFWcorr) were used to assess differences in white matter microstructure by sex, race, and APOE-ε4 carrier status. Results: Sex differences in FAFWcorr in association and projection tracts, racial differences in FAFWcorr in projection tracts, and APOE-ε4 differences in FW limbic and occipital transcallosal tracts were most pronounced. Discussion: There are prominent differences in white matter microstructure by sex, race, and APOE-ε4 carrier status. This work adds to our understanding of disparities in AD. Additional work to understand the etiology of these differences is warranted.
dc.eprint.versionFinal published version
dc.identifier.citationPeterson A, Sathe A, Zaras D, et al. Sex, racial, and APOE-ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease. Preprint. bioRxiv. 2024;2024.06.10.598357. Published 2024 Jun 12. doi:10.1101/2024.06.10.598357
dc.identifier.urihttps://hdl.handle.net/1805/43056
dc.language.isoen_US
dc.publisherbioRxiv
dc.relation.isversionof10.1101/2024.06.10.598357
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourcePMC
dc.subjectSex
dc.subjectRace
dc.subjectApolipoprotein E (APOE)
dc.subjectAlzheimer's disease (AD)
dc.titleSex, racial, and APOE-ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer’s disease
dc.typeArticle
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