HLA-B*53:01 is a significant risk factor for liver injury due to phenytoin and other anti-epileptic drugs in African Americans

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dc.contributor.authorNicoletti, Paola
dc.contributor.authorDellinger, Andrew
dc.contributor.authorLi, Yi-Ju
dc.contributor.authorBarnhart, Huiman
dc.contributor.authorPhillips, Elizabeth
dc.contributor.authorChalasani, Naga
dc.contributor.authorDrug Induced Liver Injury Network (DILIN) investigators
dc.contributor.departmentMedicine, School of Medicine
dc.date.accessioned2025-03-03T11:51:31Z
dc.date.available2025-03-03T11:51:31Z
dc.date.issued2024
dc.description.abstractIntroduction: To investigate human leukocyte antigen alleles associated with liver injury due to antiepileptic drugs (AEDs) in African Americans (AA). Methods: In this study, 21 AA with AED drug-induced liver injury (DILI), 176 AA with DILI due to non-AEDs, and 5816 AA population controls were included. Results: HLA-B*53:01 was significantly associated with aromatic AED-DILI (odds ratio: 4.52, 95% confidence interval: 2.42-8.44, P = 1.46 × 10 -5 ). Phenytoin DILI showed the strongest association with HLA-B*53:01 (odds ratio: 9.17; 95% confidence interval: 3.61-23.28, P = 1.1 × 10 -5 ). The HLA-B*53:01 allele was carried by 8 of 9 AA phenytoin DILI cases. Discussion: HLA-B*53:01 is a significant risk factor of liver injury due to antiepileptics, particularly phenytoin, in AA.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationNicoletti P, Dellinger A, Li YJ, et al. HLA-B*53:01 Is a Significant Risk Factor of Liver Injury due to Phenytoin and Other Antiepileptic Drugs in African Americans. Am J Gastroenterol. 2024;119(1):200-202. doi:10.14309/ajg.0000000000002454
dc.identifier.urihttps://hdl.handle.net/1805/46168
dc.language.isoen_US
dc.publisherWolters Kluwer
dc.relation.isversionof10.14309/ajg.0000000000002454
dc.relation.journalThe American Journal of Gastroenterology
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectAnticonvulsants
dc.subjectChemical and drug induced liver injury
dc.subjectPhenytoin
dc.titleHLA-B*53:01 is a significant risk factor for liver injury due to phenytoin and other anti-epileptic drugs in African Americans
dc.typeArticle
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