Longitudinal relationships between fatigue and depression in cancer patients with depression and/or pain

dc.contributor.authorBrown, Linda F.
dc.contributor.authorRand, Kevin L.
dc.contributor.authorBigatti, Silvia M.
dc.contributor.authorStewart, Jesse C.
dc.contributor.authorTheobald, Dale E.
dc.contributor.authorWu, Jingwei
dc.contributor.authorKroenke, Kurt
dc.contributor.departmentSocial and Behavioral Sciences, Richard M. Fairbanks School of Public Healthen_US
dc.date.accessioned2016-02-25T20:42:50Z
dc.date.available2016-02-25T20:42:50Z
dc.date.issued2013-12
dc.description.abstractOBJECTIVE: Fatigue is one of the most common and debilitating symptoms reported by cancer patients, yet relatively little is understood about its etiology. Recently, as researchers have begun to focus attention on cancer-related fatigue (CRF), depression has emerged as its strongest correlate. Few longitudinal studies, however, have examined directionality of the relationship between the two symptoms. Our aim was to evaluate the directionality of the association between depression and CRF. METHOD: The study used a single-group cohort design of longitudinal data (N = 329) from a randomized controlled trial of an intervention for pain and depression in a heterogeneous sample of cancer patients. Participants met criteria for clinically significant pain and/or depression. Our hypothesis that depression would predict change in fatigue over 3 months was tested using latent variable cross-lagged panel analysis. RESULTS: Depressive symptoms and fatigue were strongly correlated in the sample (baseline correlation of latent variables = 0.71). Although the model showed good fit to the data, χ(2) (66, N = 329) = 88.16, p = .04, SRMR = 0.030, RMSEA = 0.032, and CFI = 1.00, neither structural path linking depression and fatigue was significant, suggesting neither symptom preceded and predicted the other. CONCLUSIONS: Our findings did not support hypotheses regarding the directionality of the relationship between depressive symptoms and fatigue. The clinical implication is that depression-specific treatments may not be sufficient to treat CRF and that instead, interventions specifically targeting fatigue are needed.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationBrown, L. F., Rand, K. L., Bigatti, S. M., Stewart, J. C., Theobald, D. E., Wu, J., & Kroenke, K. (2013). Longitudinal Relationships Between Fatigue and Depression In Cancer Patients with Depression and/or Pain. Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association, 32(12), 1199–1208. http://doi.org/10.1037/a0029773en_US
dc.identifier.issn1930-7810en_US
dc.identifier.urihttps://hdl.handle.net/1805/8506
dc.language.isoen_USen_US
dc.publisherAmerican Psychological Associationen_US
dc.relation.isversionof10.1037/a0029773en_US
dc.relation.journalHealth Psychology: Official Journal of the Division of Health Psychology, American Psychological Associationen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectDepressionen_US
dc.subjectComplicationsen_US
dc.subjectFatigueen_US
dc.subjectpsychologyen_US
dc.subjectNeoplasmsen_US
dc.subjectPainen_US
dc.subjectcanceren_US
dc.subjectstructural equation modelingen_US
dc.titleLongitudinal relationships between fatigue and depression in cancer patients with depression and/or painen_US
dc.typeArticleen_US
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